Mierke Claudia Tanja
a Faculty of Physics and Earth Science; Institute of Experimental Physics I; Biological Physics Division; University of Leipzig ; Leipzig , Germany.
Cell Adh Migr. 2015;9(5):367-79. doi: 10.1080/19336918.2015.1066958.
Cellular motility is essential for many processes such as embryonic development, wound healing processes, tissue assembly and regeneration, immune cell trafficing and diseases such as cancer. The migration efficiency and the migratory potential depend on the type of migration mode. The previously established migration modes such as epithelial (non-migratory) and mesenchymal (migratory) as well as amoeboid (squeezing motility) relay mainly on phenomenological criteria such as cell morphology and molecular biological criteria such as gene expression. However, the physical view on the migration modes is still not well understood. As the process of malignant cancer progression such as metastasis depends on the migration of single cancer cells and their migration mode, this review focuses on the different migration strategies and discusses which mechanical prerequisites are necessary to perform a special migration mode through a 3-dimensional microenvironment. In particular, this review discusses how cells can distinguish and finally switch between the migration modes and what impact do the physical properties of cells and their microenvironment have on the transition between the novel migration modes such as blebbing and protrusive motility.
细胞运动对于许多过程至关重要，如胚胎发育、伤口愈合过程、组织组装与再生、免疫细胞运输以及癌症等疾病。迁移效率和迁移潜能取决于迁移模式的类型。先前确立的迁移模式，如上皮（非迁移性）和间充质（迁移性）以及阿米巴样（挤压运动），主要依赖于诸如细胞形态等现象学标准以及诸如基因表达等分子生物学标准。然而，对于迁移模式的物理学观点仍未得到充分理解。由于诸如转移等恶性癌症进展过程取决于单个癌细胞的迁移及其迁移模式，本综述聚焦于不同的迁移策略，并讨论在三维微环境中执行特定迁移模式需要哪些机械学先决条件。特别是，本综述讨论细胞如何区分并最终在迁移模式之间切换，以及细胞及其微环境的物理特性对诸如泡状运动和突出运动等新型迁移模式之间的转变有何影响。
