Kawase Rie, Nagata Shinji, Onoyama Mieko, Nakayama Nana, Honda Yohji, Kuwahara Kenichi, Kimura Shigeru, Tsuji Keiji, Ohgoshi Hiroaki, Sakatani Akio, Kaneko Mayumi, Ito Masanori, Shimamoto Fumio, Hidaka Tohru
Department of Internal Medicine, Asa-City Hospital, Hiroshima, Japan.
Department of Endoscopy, Asa-City Hospital, 2-1-1, Kabeminami, Asakita-ku, Hiroshima, Japan.
Clin J Gastroenterol. 2009 Aug;2(4):279-283. doi: 10.1007/s12328-009-0096-6. Epub 2009 Jun 25.
A rare case of gastric adenocarcinoma arising on the surface of a fundic gland polyp is reported. A 36-year-old Japanese woman was referred to our hospital for examination and treatment of a polyp that had been detected in another hospital. She did not have a history of familial adenomatous polyposis (FAP). Endoscopic examination revealed a 10-mm-diameter fundic gland polyp in the body of the stomach. The polyp had an irregular depression on its top, suggesting the presence of malignancy. Endoscopic mucosal resection was done to make a histological diagnosis. This revealed a fundic gland polyp with a tiny superficial adenocarcinoma. Atrophic changes of the gastric mucosa were mild, although Helicobacter pylori infection was positive. It is suggested that fundic gland polyps have the potential for malignant transformation.
报告了一例罕见的发生在胃底腺息肉表面的胃腺癌病例。一名36岁的日本女性因在另一家医院检测出息肉而被转诊至我院进行检查和治疗。她没有家族性腺瘤性息肉病（FAP）病史。内镜检查发现胃体部有一个直径10毫米的胃底腺息肉。息肉顶部有不规则凹陷，提示存在恶性病变。进行了内镜黏膜切除术以做出组织学诊断。结果显示为胃底腺息肉伴微小表浅腺癌。尽管幽门螺杆菌感染呈阳性，但胃黏膜的萎缩性改变较轻。提示胃底腺息肉有恶变的可能。
