Vassallo Ian Mario, Formosa Cynthia
Department of Health, Valletta, Malta.
Faculty of Health Sciences, University of Malta, Msida, Malta Address correspondence to: Cynthia Formosa, PhD, SR Pod, MPodA Faculty of Health Sciences University of Malta Tal-Qroqq Msida, Malta
Wounds. 2015 Jul;27(7):180-90.
Several treatment modalities and protocols for arterial wound ulcers are available; however, little consensus exists on which treatment modality provides the best results. The present study sought to compare and evaluate the clinical efficacy of vacuum-assisted closure wound therapy to calcium alginate dressings in the treatment of neuroischemic diabetic foot ulceration.
A single-center quasi-experimental matched subject clinical trial was conducted on 30 subjects living with type 2 diabetes and presenting with a newly diagnosed neuroischemic foot ulceration. Subjects were divided into 2 groups. Group A (n = 15) underwent negative pressure wound therapy and Group B (n =15) underwent treatment using calcium alginate dressings. Ulcer area and depth were measured during the trial.
Both negative pressure therapy and calcium alginate dressings were effective in reducing the surface area and depth of ulcers (P = 0.0001). However, negative pressure was 3.2 times more effective in reducing surface area and 3.78 times more effective in reducing depth of ulcers when compared to calcium alginate (P = 0.0001).
Vacuum-assisted closure should be considered as the treatment of choice for neuroischemic ulceration owing to its advantages in reducing surface area and depth when compared to calcium alginate dressings. Improved care could result in improved health outcomes, improved quality of life, and fewer diabetes-related foot complications.
目前有多种治疗动脉创伤性溃疡的方法和方案；然而，对于哪种治疗方法能取得最佳效果，几乎没有达成共识。本研究旨在比较和评估负压封闭引流伤口治疗与藻酸钙敷料在治疗神经缺血性糖尿病足溃疡方面的临床疗效。
对30名2型糖尿病患者且新诊断为神经缺血性足部溃疡的患者进行了一项单中心准实验性匹配受试者临床试验。受试者分为两组。A组（n = 15）接受负压伤口治疗，B组（n = 15）使用藻酸钙敷料进行治疗。在试验期间测量溃疡面积和深度。
负压治疗和藻酸钙敷料均能有效减少溃疡的表面积和深度（P = 0.0001）。然而，与藻酸钙相比，负压在减少溃疡表面积方面的效果是其3.2倍，在减少溃疡深度方面的效果是其3.78倍（P = 0.0001）。
由于负压封闭引流在减少溃疡表面积和深度方面比藻酸钙敷料更具优势，应将其视为神经缺血性溃疡的首选治疗方法。改善护理可带来更好的健康结果、更高的生活质量以及更少的糖尿病相关足部并发症。
