Sayag J, Meaume S, Bohbot S
J Wound Care. 1996 Sep;5(8):357-62.
In a prospective, randomised, controlled trial of 92 patients with full-thickness pressure ulcers, the efficacy of an alginate wound dressing was compared to that of an established local treatment with dextranomer paste. During treatment, a minimal 40% reduction in wound area was obtained in 74% of the patients in the alginate group and in 42% of those in the dextranomer group. The median time taken to achieve this goal was four weeks with alginate and more than eight weeks in the control group. Mean surface area reduction per week was 2.39 cm2 (sd 3.54) and 0.27 cm2 (sd 3.21) in the alginate and dextranomer groups respectively (p = 0.0001). This difference was still highly significant when the sub-groups of almost completely healed subjects at the end of the study were considered. This striking healing efficacy of an alginate dressing suggests it possesses pharmacological properties which require further investigation.
在一项针对92例全层压疮患者的前瞻性、随机、对照试验中，将藻酸盐伤口敷料的疗效与已确立的葡聚糖omer糊剂局部治疗的疗效进行了比较。在治疗期间，藻酸盐组74%的患者伤口面积至少减少了40%，而葡聚糖omer组为42%。使用藻酸盐实现这一目标的中位时间为四周，而对照组则超过八周。藻酸盐组和葡聚糖omer组每周平均表面积减少分别为2.39平方厘米（标准差3.54）和0.27平方厘米（标准差3.21）（p = 0.0001）。当考虑研究结束时几乎完全愈合的受试者亚组时，这种差异仍然非常显著。藻酸盐敷料这种显著的愈合效果表明它具有需要进一步研究的药理特性。
