Ersoy Murat, Selcuk Duru Hatice Nilgun, Elevli Murat, Ersoy Ozlem, Civilibal Mahmut
Department of Pediatrics, Istanbul Education and Research Hospital, Istanbul, Turkey.
Department of Pediatrics, Haseki Education and Research Hospital, Istanbul, Turkey.
Iran J Pediatr. 2015 Apr;25(2):e368. doi: 10.5812/ijp.368. Epub 2015 Apr 18.
Diabetes mellitus type 1 is the most common endocrine metabolic disorder occurring in childhood and adolescence due to the autoimmune destruction of pancreatic beta cells as a result of various environmental factors interacting with an underlying genetic predisposition. Diabetes is a risk factor for early onset atherosclerosis, and the high mortality rate seen in these patients is partially related to cardiovascular diseases.
This study was conducted to compare mean platelet volume as a marker of early atherosclerosis with aortic intima-media thickness in children with type 1 diabetes and to identify its correlation with known cardiovascular risk factors.
The study included 27 patients between age range of 6 and 17 years that were diagnosed with type 1 diabetes and 30 healthy children of the same age range who did not have any chronic disease. In both groups, we used the color Doppler ultrasound to measure children's aortic intima-media thickness and identify their mean platelet volumes.
There was no significant difference between the groups regarding gender distribution, age, High-Density Lipoprotein (HDL) and Low-Density Lipoprotein (LDL) cholesterol levels (P > 0.05). Also no significant difference could be documented between the patient and control groups regarding the aortic intima-media thickness and mean platelet volume (P > 0.05). However, there was a significant correlation between aortic intima-media thickness and mean platelet volume (r = 0.351; P < 0.05).
In the present study, there was no evidence of early atherosclerosis in children with type 1 diabetes. However, mean platelet volume having a significant correlation with aortic intima-media thickness may be useful as an early marker of atherosclerosis.
1型糖尿病是儿童和青少年中最常见的内分泌代谢紊乱疾病，其病因是多种环境因素与潜在的遗传易感性相互作用，导致胰腺β细胞发生自身免疫性破坏。糖尿病是早发性动脉粥样硬化的危险因素，这些患者的高死亡率部分与心血管疾病有关。
本研究旨在比较1型糖尿病患儿作为早期动脉粥样硬化标志物的平均血小板体积与主动脉内膜中层厚度，并确定其与已知心血管危险因素的相关性。
该研究纳入了27例年龄在6至17岁之间被诊断为1型糖尿病的患者以及30例年龄范围相同且无任何慢性病的健康儿童。在两组中，我们使用彩色多普勒超声测量儿童的主动脉内膜中层厚度并确定其平均血小板体积。
两组在性别分布、年龄、高密度脂蛋白（HDL）和低密度脂蛋白（LDL）胆固醇水平方面无显著差异（P>0.05）。患者组和对照组在主动脉内膜中层厚度和平均血小板体积方面也无显著差异（P>0.05）。然而，主动脉内膜中层厚度与平均血小板体积之间存在显著相关性（r = 0.351；P<0.05）。
在本研究中，没有证据表明1型糖尿病患儿存在早期动脉粥样硬化。然而，平均血小板体积与主动脉内膜中层厚度存在显著相关性，可能作为动脉粥样硬化的早期标志物。
