Vargas Rafael Antonio, Sarmiento Karen, Vásquez Isabel Cristina
Departamento de Ciencias Fisiológicas, Facultad de Medicina, Pontificia Universidad Javeriana , Bogotá, Colombia .
Zebrafish. 2015 Oct;12(5):320-6. doi: 10.1089/zeb.2015.1102. Epub 2015 Jul 21.
Zebrafish are an emerging basic biomedical research model that has multiple advantages compared with other research models. Given that biotoxins, such as toxins, poisons, and venoms, represent health hazards to animals and humans, a low-cost biological model that is highly sensitive to biotoxins is useful to understand the damage caused by such agents and to develop biological tests to prevent and reduce the risk of poisoning in potential cases of bioterrorism or food contamination. In this article, a narrative review of the general aspects of zebrafish as a model in basic biomedical research and various studies in the field of toxinology that have used zebrafish as a biological model are presented. This information will provide useful material to beginner students and researchers who are interested in developing toxinological studies with the zebrafish model.
斑马鱼是一种新兴的基础生物医学研究模型，与其他研究模型相比具有多种优势。鉴于生物毒素，如毒素、毒物和毒液，对动物和人类健康构成危害，一种对生物毒素高度敏感的低成本生物模型有助于了解此类物质造成的损害，并开发生物测试以预防和降低潜在生物恐怖主义或食品污染中毒事件中的中毒风险。本文对斑马鱼作为基础生物医学研究模型的一般方面以及毒理学领域中使用斑马鱼作为生物模型的各种研究进行了叙述性综述。这些信息将为有兴趣利用斑马鱼模型开展毒理学研究的初学者和研究人员提供有用的资料。
