Yarrow Joshua F, Wronski Thomas J, Borst Stephen E
1Research Service, Department of Veterans Affairs Medical Center, North Florida/South Georgia Veterans Health System; 2Departments of Applied Physiology and Kinesiology, and 3Physiological Sciences, University of Florida; and 4Geriatrics Research, Education, and Clinical Center (GRECC), Department of Veterans Affairs Medical Center, North Florida/South Georgia Veterans Health System, Gainesville, FL.
Exerc Sport Sci Rev. 2015 Oct;43(4):222-30. doi: 10.1249/JES.0000000000000056.
Androgens and estrogens influence skeletal development and maintenance in males. However, the relative contributions of the circulating sex steroid hormones that originate from testicular/adrenal secretion versus those produced locally in bone via intracrine action require further elucidation. Our novel hypothesis is that testosterone exerts direct protective effects on the adult male skeleton independently of the actions of 5α-reductase or aromatase.
雄激素和雌激素影响男性骨骼的发育与维持。然而，源自睾丸/肾上腺分泌的循环性激素与通过内分泌作用在骨骼局部产生的性激素的相对作用，仍需进一步阐明。我们的新假说是，睾酮对成年男性骨骼发挥直接保护作用，独立于5α-还原酶或芳香化酶的作用。
