Li Minmin, Lu Chengwen, Zhang Leiming, Zhang Jianqiao, Du Yuan, Duan Sijin, Wang Tian, Fu Fenghua
Key Laboratory of Molecular Pharmacology and Drug Evaluation (Ministry of Education of China), School of Pharmacy, Yantai University, Yantai, Shandong 264005, China.
Evid Based Complement Alternat Med. 2015;2015:503617. doi: 10.1155/2015/503617. Epub 2015 Jun 25.
The present study aimed to investigate the effects of oral administration of escin on acute inflammation and intestinal mucosal injury in animal models. The effects of escin on carrageenan-induced paw edema in a rat model of acute inflammation, cecal ligation and puncture (CLP) induced intestinal mucosal injury in a mouse model, were observed. It was shown that oral administration of escin inhibits carrageenan-induced paw edema and decreases the production of prostaglandin E2 (PGE2) and cyclooxygenase- (COX-) 2. In CLP model, low dose of escin ameliorates endotoxin induced liver injury and intestinal mucosal injury and increases the expression of tight junction protein claudin-5 in mice. These findings suggest that escin effectively inhibits acute inflammation and reduces intestinal mucosal injury in animal models.
本研究旨在探讨口服七叶皂苷对动物模型急性炎症和肠黏膜损伤的影响。观察了七叶皂苷对急性炎症大鼠模型中角叉菜胶诱导的爪肿胀以及小鼠模型中盲肠结扎和穿刺（CLP）诱导的肠黏膜损伤的影响。结果表明，口服七叶皂苷可抑制角叉菜胶诱导的爪肿胀，并降低前列腺素E2（PGE2）和环氧化酶-（COX-）2的产生。在CLP模型中，低剂量七叶皂苷可改善内毒素诱导的肝损伤和肠黏膜损伤，并增加小鼠紧密连接蛋白claudin-5的表达。这些发现表明，七叶皂苷可有效抑制动物模型中的急性炎症并减轻肠黏膜损伤。
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