Cengiz Mustafa, Peker Cengiz Betül, Teixeira Andrade Alanna, Ayhanci Adnan
Department of Elementary Education, Siirt University, 561000 Siirt, Türkiye.
Department of Pathology, Eskişehir Yunus Emre State Hospital, 26130 Eskişehir, Türkiye.
Curr Issues Mol Biol. 2024 Nov 25;46(12):13471-13481. doi: 10.3390/cimb46120804.
The purpose of the current study was to find out whether escin (ES) safeguarded experimental rats against cyclophosphamide (CP)-induced kidney injury. Twenty-four rats were randomly divided into four groups ( = 6). After the examination, histological and biochemical analyses were performed to assess the alterations in kidney tissue. According to histologic and biochemical analyses, renal tissue in the CP group suffered significant damage by CP. There was a significant improvement in histological damage in the group receiving CP+ES together. This suggests that ES significantly protects the kidney's functional characteristics. The present study concludes by highlighting histological and biochemical studies to illustrate the ability of ES to cure kidney injury caused by CP and its influence on the relationship between oxidative stress, apoptosis, and renal failure.
本研究的目的是探究七叶皂苷（ES）是否能保护实验大鼠免受环磷酰胺（CP）诱导的肾损伤。24只大鼠被随机分为四组（每组n = 6）。检查后，进行组织学和生化分析以评估肾组织的变化。根据组织学和生化分析，CP组的肾组织受到CP的显著损伤。同时接受CP + ES的组在组织学损伤方面有显著改善。这表明ES能显著保护肾脏的功能特性。本研究通过突出组织学和生化研究得出结论，以阐明ES治愈CP所致肾损伤的能力及其对氧化应激、细胞凋亡和肾衰竭之间关系的影响。
