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本文引用的文献

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Cigarette smoking prevalence among adults with HIV compared with the general adult population in the United States: cross-sectional surveys.美国 HIV 成年感染者与普通成年人群体的吸烟率比较：横断面调查。
Ann Intern Med. 2015 Mar 3;162(5):335-44. doi: 10.7326/M14-0954.
2
Trends in underlying causes of death in people with HIV from 1999 to 2011 (D:A:D): a multicohort collaboration.1999 年至 2011 年期间艾滋病毒感染者的死亡根本原因趋势（D:A:D）：多队列协作研究。
Lancet. 2014 Jul 19;384(9939):241-8. doi: 10.1016/S0140-6736(14)60604-8.
3
Closing the gap: increases in life expectancy among treated HIV-positive individuals in the United States and Canada.弥合差距：美国和加拿大接受治疗的 HIV 阳性个体的预期寿命增加。
PLoS One. 2013 Dec 18;8(12):e81355. doi: 10.1371/journal.pone.0081355. eCollection 2013.
4
Primary care guidelines for the management of persons infected with HIV: 2013 update by the HIV medicine association of the Infectious Diseases Society of America.美国传染病学会艾滋病医学协会关于艾滋病毒感染者管理的初级保健指南：2013 年更新。
Clin Infect Dis. 2014 Jan;58(1):e1-34. doi: 10.1093/cid/cit665. Epub 2013 Nov 13.
5
Aging, antiretrovirals, and adherence: a meta analysis of adherence among older HIV-infected individuals.老龄化、抗逆转录病毒药物和依从性：对老年 HIV 感染者依从性的荟萃分析。
Drugs Aging. 2013 Oct;30(10):809-19. doi: 10.1007/s40266-013-0107-7.
6
HIV infection and the risk of acute myocardial infarction.HIV 感染与急性心肌梗死风险。
JAMA Intern Med. 2013 Apr 22;173(8):614-22. doi: 10.1001/jamainternmed.2013.3728.
7
Use of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine for adults with immunocompromising conditions: recommendations of the Advisory Committee on Immunization Practices (ACIP).免疫功能低下成人患者使用 13 价肺炎球菌结合疫苗和 23 价肺炎球菌多糖疫苗：免疫接种实践咨询委员会（ACIP）的建议。
MMWR Morb Mortal Wkly Rep. 2012 Oct 12;61(40):816-9.
8
Comorbid diabetes and the risk of progressive chronic kidney disease in HIV-infected adults: data from the Veterans Aging Cohort Study.合并糖尿病与 HIV 感染成年人慢性肾脏病进展风险：来自 Veterans Aging Cohort Study 的数据。
J Acquir Immune Defic Syndr. 2012 Aug 1;60(4):393-9. doi: 10.1097/QAI.0b013e31825b70d9.
9
Osteoporotic fracture risk associated with cumulative exposure to tenofovir and other antiretroviral agents.与替诺福韦和其他抗逆转录病毒药物累积暴露相关的骨质疏松性骨折风险。
AIDS. 2012 Apr 24;26(7):825-31. doi: 10.1097/QAD.0b013e32835192ae.
10
Premature age-related comorbidities among HIV-infected persons compared with the general population.HIV 感染者与普通人群相比，过早出现与年龄相关的共病。
Clin Infect Dis. 2011 Dec;53(11):1120-6. doi: 10.1093/cid/cir627. Epub 2011 Oct 13.

我64岁时你还会治疗我吗？感染HIV的老年人的护理。

Will You Still Treat Me When I'm 64? Care of the Older Adult With HIV Infection.

作者信息

Libman Howard

机构信息

Harvard Medical School and Beth Israel Medical Center, Boston, MA, USA.

出版信息

Top Antivir Med. 2015 May-Jun;23(2):97-103.

PMID:26200710
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6148936/
Abstract

HIV infection is associated with chronic immune activation that is superimposed on immunologic senescence in older adults, resulting in the acquisition of age-related diseases at younger ages. The incidence of coronary artery disease is higher among HIV-infected persons than uninfected individuals matched for age and sex. HIV infection and its treatment have been associated with premature bone loss. Lung, hepatic, and anal cancers occur at younger ages in persons with HIV infection. HIV-infected patients are living longer, and proper attention to the management of comorbidities in this population is essential. This article summarizes an IAS-USA continuing education webinar presented by Howard Libman, MD, in January 2015.

摘要

HIV感染与慢性免疫激活相关，这种激活叠加在老年人的免疫衰老之上，导致在较年轻的年龄患上与年龄相关的疾病。在年龄和性别相匹配的情况下，HIV感染者中冠状动脉疾病的发病率高于未感染者。HIV感染及其治疗与过早骨质流失有关。HIV感染者患肺癌、肝癌和肛门癌的年龄更小。HIV感染患者的寿命在延长，因此对这一人群的合并症管理给予适当关注至关重要。本文总结了2015年1月由医学博士霍华德·利布曼举办的一次美国国际艾滋病学会继续教育网络研讨会的内容。