Libman Howard
Harvard Medical School and Beth Israel Medical Center, Boston, MA, USA.
Top Antivir Med. 2015 May-Jun;23(2):97-103.
HIV infection is associated with chronic immune activation that is superimposed on immunologic senescence in older adults, resulting in the acquisition of age-related diseases at younger ages. The incidence of coronary artery disease is higher among HIV-infected persons than uninfected individuals matched for age and sex. HIV infection and its treatment have been associated with premature bone loss. Lung, hepatic, and anal cancers occur at younger ages in persons with HIV infection. HIV-infected patients are living longer, and proper attention to the management of comorbidities in this population is essential. This article summarizes an IAS-USA continuing education webinar presented by Howard Libman, MD, in January 2015.
HIV感染与慢性免疫激活相关,这种激活叠加在老年人的免疫衰老之上,导致在较年轻的年龄患上与年龄相关的疾病。在年龄和性别相匹配的情况下,HIV感染者中冠状动脉疾病的发病率高于未感染者。HIV感染及其治疗与过早骨质流失有关。HIV感染者患肺癌、肝癌和肛门癌的年龄更小。HIV感染患者的寿命在延长,因此对这一人群的合并症管理给予适当关注至关重要。本文总结了2015年1月由医学博士霍华德·利布曼举办的一次美国国际艾滋病学会继续教育网络研讨会的内容。