Nakayama K, Osol G, Halpern W
Department of Surgery, Shimane Medical University, Izumo, Japan.
Blood Vessels. 1989;26(4):235-45. doi: 10.1159/000158771.
The reactivities of porcine resistance-sized arteries (270 microns o.d.) and conductance coronary arteries (4.2 mm o.d.) were compared in the presence of a functional and morphologically intact endothelium using a pressurized in vitro preparation. In resistance vessels, acetylcholine (ACh) produced maximal diameter reductions of 42% and the EC50 was 0.19 microM. Constrictions to histamine and prostaglandin F2 alpha (PGF2 alpha), however, were either absent or minimal. In contrast, maximum diameter constrictions of conductance vessels were 19, 33 and 22% in response to ACh, histamine and PGF2 alpha, respectively. Corresponding EC50 values were 0.58, 2.8 and 2.9 microM. The significant differences in reactivity between resistance and conductance arteries underscore the potential importance of regional specialization in the coronary blood flow regulation.
使用体外加压制备方法，在功能和形态完整的内皮存在的情况下，比较了猪阻力血管（外径270微米）和传导性冠状动脉（外径4.2毫米）的反应性。在阻力血管中，乙酰胆碱（ACh）使血管直径最大减少42%，半数有效浓度（EC50）为0.19微摩尔/升。然而，对组胺和前列腺素F2α（PGF2α）的收缩反应要么不存在，要么很轻微。相比之下，传导性血管对ACh、组胺和PGF2α的最大直径收缩分别为19%、33%和22%。相应的EC50值分别为0.58、2.8和2.9微摩尔/升。阻力动脉和传导性动脉在反应性上的显著差异突出了冠状动脉血流调节中区域特化的潜在重要性。
