Zhang Zi-Cheng, Su Guan-Hua, Luo Chun-Li, Pang Ya-Lu, Wang Lin, Li Xing, Wen Jia-Hao, Zhang Jiu-Liang
College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Food Funct. 2015 Sep;6(9):3045-55. doi: 10.1039/c5fo00499c.
This study was aimed at evaluating the hypouricemic effect of the anthocyanin-rich purple sweet potato extract (APSPE). In vitro, APSPE has been proved to significantly inhibit XO activity in a dose-dependent manner. In vivo, APSPE could not only inhibit the XO activity in mouse liver, but also reduce the serum uric acid level in hyperuricemic mice and affect the expression of mRNA levels of related renal transporters, such as mURAT1, mGLUT9, mOAT1 and mOCTN2. Moreover, APSPE could effectively regulate BUN and Cr levels to normal and decrease the inflammatory cellular influx in the tubule of the hyperuricemic mice. This study indicates the potential clinical utility of APSPE as a safe and effective anti-hyperuricemia bioactive agent or functional food.
本研究旨在评估富含花青素的紫甘薯提取物（APSPE）的降尿酸作用。在体外，已证明APSPE能以剂量依赖性方式显著抑制黄嘌呤氧化酶（XO）活性。在体内，APSPE不仅能抑制小鼠肝脏中的XO活性，还能降低高尿酸血症小鼠的血清尿酸水平，并影响相关肾脏转运蛋白如mURAT1、mGLUT9、mOAT1和mOCTN2的mRNA水平表达。此外，APSPE能有效将尿素氮（BUN）和肌酐（Cr）水平调节至正常，并减少高尿酸血症小鼠肾小管中的炎性细胞浸润。本研究表明APSPE作为一种安全有效的抗高尿酸血症生物活性剂或功能性食品具有潜在的临床应用价值。
