酸樱桃对血压及特定炎症生物标志物的剂量依赖性效应：一项采用GRADE评估的随机对照试验系统评价与荟萃分析
Dose-dependent effect of tart cherry on blood pressure and selected inflammation biomarkers: A GRADE-assessed systematic review and meta-analysis of randomized controlled trials.
作者信息
Norouzzadeh Mostafa, Hasan Rashedi Minoo, Shahinfar Hossein, Rahideh Seyedeh Tayebeh
机构信息
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Student Research Committee, Faculty of Public Health Branch, Iran University of Medical Sciences, Tehran, Iran.
出版信息
Heliyon. 2023 Sep 9;9(9):e19987. doi: 10.1016/j.heliyon.2023.e19987. eCollection 2023 Sep.
OBJECTIVES
As a nutritious food, Tart cherries ( L) benefit cardiovascular health. This study aims to clarify the effectiveness of Tart cherry in controlling blood pressure, heart rate, and inflammatory biomarkers, the appropriate dosage for this effect, and suggest directions for future studies.
METHODS
PubMed, Scopus, and Web of Science were searched (up to May 2022), to identify eligible randomized controlled trials. It measured publication bias and was assessed for all outcomes. Evidence quality was evaluated using the Cochrane risk of bias tool and GRADE (Grades of Recommendations, Assessment, Development, and Evaluations)
RESULTS
Regarding the 21 included trials, Tart cherry didn't affect blood pressure, heart rate, high-sensitive C-reactive protein, and interleukin-6 (P > 0.05). In contrast, with moderate certainty, it can reduce serum C-reactive protein (WMD: - 0.39 mg/l; 95% CI: - 0.74, - 0.05; P = 0.024) and with very low certainty can decrease tumor necrosis factor-alpha (WMD: - 0.14 pg/ml; 95% CI: - 0.27, - 0.02; P = 0.026). In addition, dose-response analysis implies that with each 30 ml elevation in dose, CRP reduces by 0.19 mg/l (95% CI: - 0.37, - 0.01).
CONCLUSIONS
Tart cherry can control inflammation by administering the proper dose. Even though tart cherry generally doesn't affect blood pressure and heart rate, further high-quality studies are needed to determine its effect.
目的
酸樱桃作为一种营养丰富的食物，对心血管健康有益。本研究旨在阐明酸樱桃在控制血压、心率和炎症生物标志物方面的有效性、产生该效果的合适剂量，并为未来研究提供方向。
方法
检索了PubMed、Scopus和Web of Science（截至2022年5月），以确定符合条件的随机对照试验。测量了发表偏倚，并对所有结果进行了评估。使用Cochrane偏倚风险工具和GRADE（推荐分级、评估、制定和评价）对证据质量进行了评估。
结果
关于纳入的21项试验，酸樱桃对血压、心率、高敏C反应蛋白和白细胞介素-6没有影响（P>0.05）。相比之下，中等确定性地表明，它可以降低血清C反应蛋白（加权均数差：-0.39mg/l；95%可信区间：-0.74，-0.05；P=0.024），极低确定性地表明可以降低肿瘤坏死因子-α（加权均数差：-0.14pg/ml；95%可信区间：-0.27，-0.02；P=0.026）。此外，剂量反应分析表明，剂量每升高30ml，CRP降低0.19mg/l（95%可信区间：-0.37，-0.01）。
结论
酸樱桃通过给予适当剂量可以控制炎症。尽管酸樱桃一般不影响血压和心率，但仍需要进一步的高质量研究来确定其效果。
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