Jiang Lin-Lin, Gong Xue, Ji Ming-Yue, Wang Cong-Cong, Wang Jian-Hua, Li Min-Hui
Department of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China.
Department of Pharmacy, Baotou Medical College, Baotou 014060, China.
Foods. 2020 Jul 23;9(8):973. doi: 10.3390/foods9080973.
Hyperuricemia is a common metabolic disease that is caused by high serum uric acid levels. It is considered to be closely associated with the development of many chronic diseases, such as obesity, hypertension, hyperlipemia, diabetes, and cardiovascular disorders. While pharmaceutical drugs have been shown to exhibit serious side effects, and bioactive compounds from plant-based functional foods have been demonstrated to be active in the treatment of hyperuricemia with only minimal side effects. Indeed, previous reports have revealed the significant impact of bioactive compounds from plant-based functional foods on hyperuricemia. This review focuses on plant-based functional foods that exhibit a hypouricemic function and discusses the different bioactive compounds and their pharmacological effects. More specifically, the bioactive compounds of plant-based functional foods are divided into six categories, namely flavonoids, phenolic acids, alkaloids, saponins, polysaccharides, and others. In addition, the mechanism by which these bioactive compounds exhibit a hypouricemic effect is summarized into three classes, namely the inhibition of uric acid production, improved renal uric acid elimination, and improved intestinal uric acid secretion. Overall, this current and comprehensive review examines the use of bioactive compounds from plant-based functional foods as natural remedies for the management of hyperuricemia.
高尿酸血症是一种常见的代谢性疾病，由血清尿酸水平升高引起。它被认为与许多慢性疾病的发生密切相关，如肥胖、高血压、高脂血症、糖尿病和心血管疾病。虽然已证明药物具有严重的副作用，但来自植物性功能性食品的生物活性化合物已被证明在治疗高尿酸血症方面具有活性，且副作用极小。事实上，先前的报告已经揭示了植物性功能性食品中的生物活性化合物对高尿酸血症的重大影响。本综述重点关注具有降尿酸功能的植物性功能性食品，并讨论不同的生物活性化合物及其药理作用。更具体地说，植物性功能性食品的生物活性化合物分为六类，即黄酮类、酚酸类、生物碱类、皂苷类、多糖类和其他类。此外，这些生物活性化合物发挥降尿酸作用的机制总结为三类，即抑制尿酸生成、改善肾脏尿酸排泄和改善肠道尿酸分泌。总体而言，这篇全面的综述探讨了将植物性功能性食品中的生物活性化合物用作管理高尿酸血症的天然疗法。
