Department of Organic Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel.
1] Department of Organic Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel [2] Department of Chemistry, University of Southampton, Southampton SO17 1BJ, UK.
Nat Chem. 2015 Aug;7(8):646-52. doi: 10.1038/nchem.2303. Epub 2015 Jul 20.
The ability to guide the assembly of nanosized objects reversibly with external stimuli, in particular light, is of fundamental importance, and it contributes to the development of applications as diverse as nanofabrication and controlled drug delivery. However, all the systems described to date are based on nanoparticles (NPs) that are inherently photoresponsive, which makes their preparation cumbersome and can markedly hamper their performance. Here we describe a conceptually new methodology to assemble NPs reversibly using light that does not require the particles to be functionalized with light-responsive ligands. Our strategy is based on the use of a photoswitchable medium that responds to light in such a way that it modulates the interparticle interactions. NP assembly proceeds quantitatively and without apparent fatigue, both in solution and in gels. Exposing the gels to light in a spatially controlled manner allowed us to draw images that spontaneously disappeared after a specific period of time.
能够通过外部刺激（尤其是光）可逆地引导纳米尺寸物体的组装具有重要的意义，它有助于开发各种应用，如纳米制造和控制药物输送。然而，迄今为止所有描述的系统都是基于固有光响应的纳米粒子 (NPs)，这使得它们的制备繁琐，并且可以显著地阻碍它们的性能。在这里，我们描述了一种使用光来可逆地组装 NPs 的新概念方法，该方法不需要将粒子用光响应配体功能化。我们的策略基于使用光响应的介质，该介质以这样一种方式响应光，即调制粒子间的相互作用。NP 组装在溶液和凝胶中都定量且没有明显的疲劳进行。通过空间控制的方式将凝胶暴露于光线下，我们可以绘制图像，这些图像在特定时间段后会自动消失。
