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基于金纳米颗粒刺激响应性聚集的肿瘤诊断与治疗

Tumor Diagnosis and Treatment Based on Stimuli-Responsive Aggregation of Gold Nanoparticles.

作者信息

Chang Xiaowei, Wang Huaiyu, Chen Xin

机构信息

Department of Chemical Engineering, Shaanxi Key Laboratory of Energy Chemical Process Intensification, Institute of Polymer Science in Chemical Engineering, School of Chemical Engineering and Technology Xi'an Jiaotong University Xi'an China.

The First Affiliated Hospital of Xi'an Jiaotong University Xi'an China.

出版信息

Exploration (Beijing). 2025 Feb 6;5(3):270006. doi: 10.1002/EXP.70006. eCollection 2025 Jun.

DOI:10.1002/EXP.70006
PMID:40585773
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12199428/
Abstract

Gold nanomaterials have been used in the diagnosis and treatment of different tumors due to their unique physical and chemical properties. Among them, gold nanoparticles with stimuli-responsive aggregation functions have attracted extensive attention because they can meet the unique needs of tumor diagnosis and treatment at different stages through structural changes. However, how to effectively modify gold nanoparticles to achieve structural transformation for specific stimuli, and the role of corresponding structural transformation in improving the effect of diagnosis and treatment still lack systematic summary. In this review, we comprehensively summarized the current strategies for inducing gold nanoparticles aggregation and its advances in tumor diagnosis and treatment.

摘要

由于其独特的物理和化学性质，金纳米材料已被用于不同肿瘤的诊断和治疗。其中，具有刺激响应聚集功能的金纳米颗粒因其能够通过结构变化满足不同阶段肿瘤诊断和治疗的独特需求而备受关注。然而，如何有效修饰金纳米颗粒以实现对特定刺激的结构转变，以及相应的结构转变在提高诊疗效果中的作用仍缺乏系统总结。在本综述中，我们全面总结了目前诱导金纳米颗粒聚集的策略及其在肿瘤诊断和治疗方面的进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b204/12199428/c7edde61e70f/EXP2-5-270006-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b204/12199428/acb237e0852d/EXP2-5-270006-g004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b204/12199428/3e5c7dd4b08a/EXP2-5-270006-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b204/12199428/2e359eca6156/EXP2-5-270006-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b204/12199428/907de2dc882f/EXP2-5-270006-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b204/12199428/a77f57a16529/EXP2-5-270006-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b204/12199428/41d8c1f5a0b0/EXP2-5-270006-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b204/12199428/dc6cb099868f/EXP2-5-270006-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b204/12199428/84b1f8651f4b/EXP2-5-270006-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b204/12199428/45f2847bacf4/EXP2-5-270006-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b204/12199428/c7edde61e70f/EXP2-5-270006-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b204/12199428/acb237e0852d/EXP2-5-270006-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b204/12199428/83da5e8391d2/EXP2-5-270006-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b204/12199428/bddd3d09ab22/EXP2-5-270006-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b204/12199428/3e5c7dd4b08a/EXP2-5-270006-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b204/12199428/2e359eca6156/EXP2-5-270006-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b204/12199428/907de2dc882f/EXP2-5-270006-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b204/12199428/a77f57a16529/EXP2-5-270006-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b204/12199428/41d8c1f5a0b0/EXP2-5-270006-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b204/12199428/dc6cb099868f/EXP2-5-270006-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b204/12199428/84b1f8651f4b/EXP2-5-270006-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b204/12199428/45f2847bacf4/EXP2-5-270006-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b204/12199428/c7edde61e70f/EXP2-5-270006-g010.jpg

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