Palou Mariona, Sánchez Juana, García-Carrizo Francisco, Palou Andreu, Picó Catalina
Laboratory of Molecular Biology, Nutrition and Biotechnology (Nutrigenomics), University of the Balearic Islands and CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Palma de Mallorca, Balearic Islands, Spain.
Mol Nutr Food Res. 2015 Oct;59(10):2022-33. doi: 10.1002/mnfr.201500292. Epub 2015 Sep 7.
This study investigates whether pectin supplementation in adult rats can ameliorate age-associated disturbances in peripheral insulin and leptin actions.
Seven-month-old male Wistar rats were divided into three groups: control (rats fed ad libitum a standard-diet), pectin (rats fed ad libitum a standard-diet supplemented with 10% pectin), and pair-fed (rats pair-fed to the pectin group). They were sacrificed after 1 month. Pectin and pair-fed rats showed lower body weight gain and food intake than controls and underwent a decrease in leptin levels and an increase in adiponectin levels. Pectin-treated animals, but not pair-fed ones, showed lower body-fat content and HOMA-IR index after dietary intervention. Compared to controls, pectin-treated rats showed a decline in the expression of genes related to energy uptake (WAT) and lipogenesis (WAT and liver), and increased expression levels of lipolysis- and fatty-acid oxidation-related genes (liver). Some of the changes were not evidenced in the pair-fed group. These effects appear to be associated with improved leptin signaling.
Ten percent pectin supplementation for 1 month in adult rats decreases body-fat content and ameliorates age-related insulin and leptin resistance more intensely than what could be attributed to the decrease in energy intake, overall contributing to better metabolic health.
本研究调查了成年大鼠补充果胶是否能改善与年龄相关的外周胰岛素和瘦素作用紊乱。
将7月龄雄性Wistar大鼠分为三组：对照组（自由采食标准饮食的大鼠）、果胶组（自由采食添加10%果胶的标准饮食的大鼠）和配对喂养组（与果胶组大鼠配对喂养的大鼠）。1个月后将它们处死。果胶组和配对喂养组大鼠的体重增加和食物摄入量低于对照组，瘦素水平降低，脂联素水平升高。饮食干预后，果胶处理的动物（而非配对喂养的动物）体脂含量和HOMA-IR指数较低。与对照组相比，果胶处理的大鼠与能量摄取（白色脂肪组织）和脂肪生成（白色脂肪组织和肝脏）相关的基因表达下降，与脂肪分解和脂肪酸氧化相关的基因（肝脏）表达水平升高。配对喂养组未出现其中一些变化。这些作用似乎与改善瘦素信号有关。
成年大鼠补充10%果胶1个月可降低体脂含量，并比能量摄入减少更显著地改善与年龄相关的胰岛素和瘦素抵抗，总体上有助于改善代谢健康。
