Laboratory of Molecular Biology, Nutrition and Biotechnology (Nutrigenomics, Biomarkers and Risk Evaluation-NuBE), University of the Balearic Islands, 07122 Palma, Spain.
Department of Adipocyte Development and Nutrition (ADE), German Institute of Human Nutrition (DIfE), 14558 Potsdam-Rehbrücke, Germany.
J Agric Food Chem. 2022 Oct 19;70(41):13200-13211. doi: 10.1021/acs.jafc.2c03143. Epub 2022 Oct 10.
Supplementation with the prebiotic pectin is associated with beneficial health effects. We aimed to characterize the cardioprotective actions of chronic high-esterified pectin (HEP) supplementation (10%) in a model of metabolic malprogramming in rats, prone to obesity and associated disorders: the progeny of mild calorie-restricted dams during the first half of pregnancy. Results show that pectin supplementation reverses metabolic malprogramming associated with gestational undernutrition. In this sense, HEP supplementation improved blood pressure, reduced heart lipid content, and regulated cardiac gene expression of atrial natriuretic peptide and lipid metabolism-related genes. Moreover, it caused an elevation in circulating levels of fibroblast growth factor 21 and a higher expression of its co-receptor β-klotho in the heart. Most effects are correlated with the gut levels of beneficial bacteria promoted by HEP. Therefore, chronic HEP supplementation shows cardioprotective actions, and hence, it is worth considering as a strategy to prevent programmed cardiometabolic alterations.
补充益生元果胶与有益的健康效果有关。我们旨在描述慢性高酯化果胶（HEP）补充（10％）在代谢编程模型中的心脏保护作用，该模型易患肥胖症和相关疾病：在妊娠前半段期间轻度热量限制的母鼠的后代。结果表明，果胶补充可逆转与妊娠营养不足相关的代谢编程。在这个意义上，HEP 补充改善了血压，降低了心脏脂质含量，并调节了心钠肽和脂质代谢相关基因的心脏基因表达。此外，它导致成纤维细胞生长因子 21 的循环水平升高，并且在心脏中其共同受体 β-klotho 的表达更高。大多数作用与 HEP 促进的有益细菌的肠道水平相关。因此，慢性 HEP 补充具有心脏保护作用，因此值得考虑作为预防编程性心脏代谢改变的策略。
