Gonçalves R H, Castro-e-Silva Júnior O, Franco C F, Souza M E, Picinato M A, Mazzetto S A, Ceneviva R
Departamento de Cirurgia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brasil.
Braz J Med Biol Res. 1989;22(6):799-802.
The rat is an experimental model of orthotopic liver transplant that does not need arterial revascularization of the transplanted liver. The objective of the present study was to investigate the effect of hepatic artery ligation on hepatic metabolism in rats. After 2, 3 or 24 h of hepatic artery ligation, no significant differences in serum levels of alanine aminotransferase were observed. Bile flow decreased significantly 3 h after arterial ligation (P less than 0.05) and returned to normal after 24 h (P less than 0.05).
大鼠是原位肝移植的实验模型，不需要对移植肝脏进行动脉血管重建。本研究的目的是探讨肝动脉结扎对大鼠肝脏代谢的影响。肝动脉结扎2、3或24小时后，血清丙氨酸转氨酶水平未观察到显著差异。动脉结扎3小时后胆汁流量显著下降（P<0.05），24小时后恢复正常（P<0.05）。
