Soares A F, Castro-e-Silva Júnior O, Watanabe L M, Roselino J E, Ceneviva R
Setor de Técnica Cirúrgica e Cirurgia Experimental, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brasil.
Braz J Med Biol Res. 1990;23(6-7):543-5.
Because of the liver's dependence on arterial blood to exert its metabolic functions in cirrhosis of the liver, with or without thrombosis of the portal vein, the interruption of hepatic arterial flow for the palliative treatment of malignant tumors of the liver is counterindicated. However, the effects of arterial devascularization on the cholestatic liver are not fully understood. The objective of the present study was to investigate hepatic alterations due to hepatic artery ligation in rats with chronic extrahepatic cholestasis. Serum alkaline phosphatase, bilirubin and alanine aminotransferase were measured in rats 3 h after sham operation (group A, N = 29) or ligation of the hepatic artery (group B, N = 29). Alanine aminotransferase activity was significantly higher (P less than 0.05) in group B, demonstrating acute hepatocellular damage in animals with chronic extrahepatic cholestasis.
由于肝脏在肝硬化时依赖动脉血来发挥其代谢功能，无论有无门静脉血栓形成，均禁忌为姑息治疗肝脏恶性肿瘤而中断肝动脉血流。然而，动脉去血管化对胆汁淤积性肝脏的影响尚未完全明确。本研究的目的是探讨慢性肝外胆汁淤积大鼠肝动脉结扎后的肝脏改变。在假手术（A组，N = 29）或肝动脉结扎（B组，N = 29）3小时后，测量大鼠血清碱性磷酸酶、胆红素和丙氨酸转氨酶水平。B组丙氨酸转氨酶活性显著升高（P < 0.05），表明慢性肝外胆汁淤积动物存在急性肝细胞损伤。
