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头皮银屑病的罕见表现:临床、 trichoscopic 和组织病理学特征及文献复习。

Uncommon Presentation of Pityriasis Rubra Pilaris of the Scalp: Clinical, Trichoscopic, and Histopathologic Features and Review of the Literature.

机构信息

Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola-Malpighi, 40138 Bologna, Italy.

Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy.

出版信息

Medicina (Kaunas). 2024 Nov 8;60(11):1839. doi: 10.3390/medicina60111839.

DOI:10.3390/medicina60111839
PMID:39597024
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11596965/
Abstract

Pityriasis rubra pilaris (PRP) presents a diagnostic challenge due to its varied clinical manifestations and the scarce literature on scalp involvement. This article presents a case report of a 59-year-old female with PRP solely affecting the scalp, detailing its clinical, trichoscopic, and histopathological features. Trichoscopy revealed a novel finding of white-silvery scales forming hair casts with a triangular shape, distinct from the existing literature. A literature review comparing our findings with pertinent articles underscored the uniqueness of our case. We discuss differential diagnoses and treatment options, based on available evidence. Our case highlights the importance of understanding scalp manifestations in PRP, enhancing diagnostic accuracy, and improving treatment strategies for this rare condition. Furthermore, the review of the literature compares our observations with available case reports and case series, outlining differential diagnoses and trichoscopic and histopathological diagnostic approaches to PRP, enriching overall clinical knowledge of PRP.

摘要

红糠疹(PRP)因其临床表现多样,头皮受累的文献稀少,诊断具有挑战性。本文报告了一例仅累及头皮的 59 岁女性 PRP 病例,详细描述了其临床、毛发镜和组织病理学特征。毛发镜检查显示了一种新的发现,即白色银灰色鳞屑形成三角形的发套,与现有文献不同。与相关文章的文献回顾比较了我们的发现,突出了我们病例的独特性。我们根据现有证据讨论了鉴别诊断和治疗选择。我们的病例强调了理解 PRP 头皮表现的重要性,提高了诊断准确性,并改善了这种罕见疾病的治疗策略。此外,文献回顾将我们的观察结果与现有的病例报告和病例系列进行了比较,概述了 PRP 的鉴别诊断和毛发镜及组织病理学诊断方法,丰富了 PRP 的整体临床知识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1288/11596965/b4ef6cb1a9e7/medicina-60-01839-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1288/11596965/270c27d6d799/medicina-60-01839-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1288/11596965/b4ef6cb1a9e7/medicina-60-01839-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1288/11596965/270c27d6d799/medicina-60-01839-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1288/11596965/b4ef6cb1a9e7/medicina-60-01839-g002.jpg

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Uncommon Presentation of Pityriasis Rubra Pilaris of the Scalp: Clinical, Trichoscopic, and Histopathologic Features and Review of the Literature.头皮银屑病的罕见表现:临床、 trichoscopic 和组织病理学特征及文献复习。
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本文引用的文献

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Tofacitinib for Pityriasis Rubra Pilaris: A Case Report.托法替布治疗毛发红糠疹:一例报告
Clin Cosmet Investig Dermatol. 2024 Aug 26;17:1917-1920. doi: 10.2147/CCID.S470170. eCollection 2024.
2
Successful Treatment of Generalized Pustular Psoriasis Coexisting with Pityriasis Rubra Pilaris with Upadacitinib.乌帕替尼成功治疗与毛发红糠疹共存的泛发性脓疱型银屑病
Indian J Pediatr. 2024 Dec;91(12):1296. doi: 10.1007/s12098-024-05214-x. Epub 2024 Aug 1.
3
Updates on Pityriasis Rubra Pilaris: A Scoping Review.关于红癣:范围综述的最新进展。
J Cutan Med Surg. 2024 Mar-Apr;28(2):158-166. doi: 10.1177/12034754231223159. Epub 2024 Jan 4.
4
Psoriasis and skin cancer - Is there a link?银屑病与皮肤癌——二者是否存在关联?
Int Immunopharmacol. 2023 Aug;121:110464. doi: 10.1016/j.intimp.2023.110464. Epub 2023 Jun 28.
5
Pityriasis Rubra Pilaris Transcriptomics Implicate T Helper 17 Signaling and Correlate with Response to Ixekizumab, with Distinct Gene Expression Profiles in Nonresponders.红皮病型毛发红糠疹的转录组学研究表明辅助性T细胞17信号传导参与其中,并与对司库奇尤单抗的反应相关,无反应者具有独特的基因表达谱。
J Invest Dermatol. 2023 Mar;143(3):501-504.e1. doi: 10.1016/j.jid.2022.09.005. Epub 2022 Sep 24.
6
An Overview of the Diagnosis and Management of Seborrheic Dermatitis.脂溢性皮炎的诊断与管理概述
Clin Cosmet Investig Dermatol. 2022 Aug 6;15:1537-1548. doi: 10.2147/CCID.S284671. eCollection 2022.
7
Secukinumab for the treatment of adult-onset pityriasis rubra pilaris: a single-arm clinical trial with transcriptomic analysis.司库奇尤单抗治疗成人发病性毛发红糠疹:一项带有转录组分析的单臂临床试验。
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J Invest Dermatol. 2022 Mar;142(3 Pt B):781-792. doi: 10.1016/j.jid.2021.07.189. Epub 2021 Dec 7.
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