眼表冷却与泪膜变薄和破裂相关。

Ocular Surface Cooling Corresponds to Tear Film Thinning and Breakup.

作者信息

Li Wing, Graham Andrew D, Selvin Steve, Lin Meng C

机构信息

*OD, FAAO †MA ‡PhD §OD, PhD, FAAO Vision Science Program, University of California, Berkeley, Berkeley, California (WL, MCL); Clinical Research Center, School of Optometry, University of California, Berkeley, Berkeley, California (WL, ADG, MCL); and School of Public Health, University of California, Berkeley, Berkeley, California (SS).

出版信息

Optom Vis Sci. 2015 Sep;92(9):e248-56. doi: 10.1097/OPX.0000000000000672.

DOI:10.1097/OPX.0000000000000672

PMID:26204474

Abstract

PURPOSE

To investigate the relationship between ocular surface temperature (OST) and tear film thinning and breakup.

METHODS

Simultaneous imaging of OST and fluorescein tear thinning and breakup (FTBU) was performed on 20 subjects. Subjects were asked to open their eyes and refrain from blinking for as long as they could during testing. Ocular surface temperature was measured using an infrared thermographic camera (FLIR A655sc) and rates of ocular surface cooling (OSC) were analyzed using commercially available software. A method was developed to quantify the rate of FTBU formation using image-processing software.

RESULTS

Areas of FTBU and regions of OSC were observed to be colocalized, with localized cooling preceding the formation of FTBU. The rates of OSC and FTBU formation were positively correlated (r = 0.74). A second-order polynomial model accurately describes the physiological relationship between the area of FTBU and OST (p < 0.001). A linear approximation provides a more clinically interpretable rate of FTBU formation with decreasing OST (p < 0.001), while still retaining high R.

CONCLUSIONS

The results suggest a direct relationship between FTBU formation and OSC. That cooling of the ocular surface precedes FTBU formation implies a process of evaporation contributing to tear film thinning and breakup. Our study suggests that measuring the OSC rate could be an indirect assessment of tear evaporation and could contribute to the management of evaporative dry eye.

摘要

目的

研究眼表温度（OST）与泪膜变薄及破裂之间的关系。

方法

对20名受试者进行了眼表温度与荧光素泪膜变薄及破裂（FTBU）的同步成像。受试者被要求在测试过程中尽可能长时间睁开眼睛并避免眨眼。使用红外热成像相机（FLIR A655sc）测量眼表温度，并使用商用软件分析眼表冷却（OSC）速率。开发了一种使用图像处理软件量化FTBU形成速率的方法。

结果

观察到FTBU区域与OSC区域共定位，在FTBU形成之前出现局部冷却。OSC速率与FTBU形成速率呈正相关（r = 0.74）。二阶多项式模型准确描述了FTBU面积与OST之间的生理关系（p < 0.001）。线性近似提供了随着OST降低更具临床可解释性的FTBU形成速率（p < 0.001），同时仍保持高相关性。