Itokawa Takashi, Okajima Yukinobu, Suzuki Takashi, Kobayashi Tatsuhiko, Tei Yuto, Kakisu Koji, Hori Yuichi
Department of Ophthalmology, Toho University Graduate School of Medicine, Tokyo, Japan.
Department of Ophthalmology, School of Medicine, Toho University, Tokyo, Japan.
J Ophthalmol. 2019 Aug 19;2019:8189097. doi: 10.1155/2019/8189097. eCollection 2019.
To investigate the association among the ocular surface temperature (OST), tear film stability, functional visual acuity (FVA), and blink rate in patients after cataract surgery.
We recruited 98 eyes of 69 patients (mean age, 73.7 ± 5.2 years) 1 month after phacoemulsification with implantation of acrylic intraocular lenses and assessed slit-lamp microscopy, corrected distance VA, FVA, noninvasive tear breakup time (NIBUT), and OST. We defined the changes in the OST from 0 to 10 seconds after eye opening as the ΔOST. We measured the FVA and blink rate using the FVA measurement system. We divided the patients into two groups based on tear film stability: stable tear film (NIBUT, >5.0 seconds) and unstable tear film (NIBUT, ≤5.0 seconds). We evaluated the differences between the two groups and the association between the blink rate and other clinical parameters.
The unstable tear film group (56 eyes) had significantly ( < 0.0001, unpaired -test) shorter NIBUTs than the stable tear film group (42 eyes). The ΔOSTs and blink rates were significantly ( < 0.0001) higher in the unstable tear film group than in the stable group. Linear single regression analysis showed that the ΔOST ( = -0.430, < 0.0001), NIBUT ( = -0.392, < 0.0001), and gender ( = -0.370, =0.0002) were correlated significantly with the blink rate. Multiple regression analysis showed that the ΔOST independently contributed to the blink rate.
The frequency of blinks is associated with tear film stability in patients after cataract surgery. The blink rate may be useful for evaluating the tear film stability in clinical practice. The ΔOST should be an important contributing factor to the blink rate. [This trial is registered with UMIN000026970].
探讨白内障手术后患者眼表温度（OST）、泪膜稳定性、功能性视力（FVA）和眨眼频率之间的关系。
我们招募了69例患者（平均年龄73.7±5.2岁）的98只眼，这些患者在白内障超声乳化吸除联合丙烯酸人工晶状体植入术后1个月，接受了裂隙灯显微镜检查、矫正远视力、FVA、非侵入性泪膜破裂时间（NIBUT）和OST评估。我们将睁眼后0至10秒的OST变化定义为ΔOST。我们使用FVA测量系统测量FVA和眨眼频率。根据泪膜稳定性将患者分为两组：泪膜稳定组（NIBUT＞5.0秒）和泪膜不稳定组（NIBUT≤5.0秒）。我们评估了两组之间的差异以及眨眼频率与其他临床参数之间的关系。
泪膜不稳定组（56只眼）的NIBUT明显（P＜0.0001，非配对t检验）短于泪膜稳定组（42只眼）。泪膜不稳定组的ΔOST和眨眼频率明显（P＜0.0001）高于稳定组。线性单因素回归分析显示，ΔOST（β=-0.430，P＜0.0001）、NIBUT（β=-0.392，P＜0.0001）和性别（β=-0.370，P=0.0002）与眨眼频率显著相关。多因素回归分析显示，ΔOST独立影响眨眼频率。
白内障手术后患者的眨眼频率与泪膜稳定性相关。眨眼频率可能有助于在临床实践中评估泪膜稳定性。ΔOST应该是眨眼频率的一个重要影响因素。[本试验已在UMIN000026970注册]
