Department of Neurological Surgery, George Washington University Medical Center, Washington, DC 20037, USA.
Ann Transl Med. 2015 Jun;3(9):121. doi: 10.3978/j.issn.2305-5839.2015.05.10.
This manuscript discusses the current surgical management of glioblastoma. This paper highlights the common pathophysiology attributes of glioblastoma, surgical options for diagnosis/treatment, current thoughts of extent of resection (EOR) of tumor, and post-operative (neo)adjuvant treatment. Glioblastoma is not a disease that can be cured with surgery alone, however safely performed maximal surgical resection is shown to significantly increase progression free and overall survival while maximizing quality of life. Upon invariable tumor recurrence, re-resection also is shown to impact survival in a select group of patients. As adjuvant therapy continues to improve survival, the role of surgical resection in the treatment of glioblastoma looks to be further defined.
这篇手稿讨论了胶质母细胞瘤的当前手术治疗方法。本文重点介绍了胶质母细胞瘤的常见病理生理学特征、诊断/治疗的手术选择、目前对肿瘤切除范围（EOR）的看法，以及术后（新）辅助治疗。胶质母细胞瘤不能仅靠手术治愈，但是安全地进行最大限度的手术切除已被证明可显著提高无进展生存期和总生存期，同时最大限度地提高生活质量。在肿瘤不可避免地复发后，再次切除也显示出对一组特定患者的生存有影响。随着辅助治疗继续提高生存率，手术切除在胶质母细胞瘤治疗中的作用似乎进一步得到了明确。
