神经连接蛋白的细胞和分子格局
The cellular and molecular landscape of neuroligins.
作者信息
Bemben Michael A, Shipman Seth L, Nicoll Roger A, Roche Katherine W
机构信息
Receptor Biology Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health, Bethesda, MD 20892, USA; Department of Biology, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD, 21218, USA.
Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.
出版信息
Trends Neurosci. 2015 Aug;38(8):496-505. doi: 10.1016/j.tins.2015.06.004. Epub 2015 Jul 21.
A fundamental physical interaction exists across the synapse. It is mediated by synaptic adhesion molecules, and is among the earliest and most indispensable of molecular events occurring during synaptogenesis. The regulation of adhesion molecules and their interactions with other synaptic proteins likely affect not only on synapse formation but also on ongoing synaptic function. We review research on one major family of postsynaptic adhesion molecules, neuroligins, which bind to their presynaptic partner neurexin across the synaptic cleft. We move from a structural overview to the broad cellular and synaptic context of neuroligins, intermolecular interactions, and molecular modifications that occur within a synapse. Finally, we examine evidence concerning the physiological functions of neuroligin in a cell and highlight areas requiring further investigation.
一种基本的物理相互作用存在于突触中。它由突触粘附分子介导，是突触形成过程中最早且最不可或缺的分子事件之一。粘附分子的调节及其与其他突触蛋白的相互作用可能不仅影响突触形成，还影响正在进行的突触功能。我们综述了关于一类主要的突触后粘附分子——神经连接蛋白的研究，它们通过突触间隙与突触前伴侣蛋白神经配蛋白结合。我们从结构概述入手，进而探讨神经连接蛋白在广泛的细胞和突触环境中的情况、分子间相互作用以及突触内发生的分子修饰。最后，我们研究了关于神经连接蛋白在细胞中的生理功能的证据，并强调了需要进一步研究的领域。
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