Discipline of Psychiatry, Sydney Medical School, University of Sydney, Royal North Shore Hospital, NSW 2065, Australia; SCAN Research and Teaching Unit, School of Psychology, University of Sydney, NSW 2006, Australia.
Discipline of Psychiatry, Sydney Medical School, University of Sydney, Royal North Shore Hospital, NSW 2065, Australia; CADE Clinic, Department of Psychiatry, Royal North Shore Hospital, NSW 2065, Australia; Advanced Research and Clinical Highfield Imaging (ARCHI), University of Sydney, Royal North Shore Hospital, NSW 2065, Australia.
Psychiatry Res. 2015 Sep 30;233(3):451-7. doi: 10.1016/j.pscychresns.2015.07.018. Epub 2015 Jul 13.
Acute antidepressant administration modulates neural activity consistent with decreases in negative emotion processing bias. However, studies are yet to examine whether treatment facilitates neural activity during reappraisal, an adaptive emotion regulation strategy associated with behavioral treatment response. Here we examine the impact of acute administration on reappraisal of negative stimuli using pharmaco-fMRI. Thirty-six healthy female participants completed two sessions of fMRI scanning, separated by a one-week washout period. A single dose of the selective serotonin reuptake inhibitor, escitalopram (20mg) was administered to participants using a double-blind, randomized, placebo-controlled crossover design. When participants were administered escitalopram (relative to a placebo) and asked to reappraise negative emotional stimuli, left amygdala activation was decreased and right inferior frontal gyrus (R IFG) activation was increased. Also observed was a greater negative left amygdala-R IFG functional connectivity when participants were administered escitalopram relative to placebo, and this change in connectivity was associated with reductions in subjective ratings of valence and arousal of negative stimuli. Further analysis revealed connectivity modulation across multiple frontal regions. Results suggest that the acute effect of a commonly prescribed antidepressant may include facilitating the regulation of negative emotional stimuli, providing new important leads for models of antidepressant action.
急性抗抑郁药物治疗可调节与负面情绪加工偏向减少一致的神经活动。然而，目前还没有研究检验治疗是否有助于再评价期间的神经活动，再评价是一种与行为治疗反应相关的适应性情绪调节策略。在这里，我们使用药物 fMRI 来研究急性给药对负面刺激再评价的影响。36 名健康女性参与者完成了两次 fMRI 扫描，两次扫描之间有一周的洗脱期。使用双盲、随机、安慰剂对照交叉设计，给参与者单次服用选择性 5-羟色胺再摄取抑制剂艾司西酞普兰（20mg）。当参与者服用艾司西酞普兰（相对于安慰剂）并被要求重新评价负面情绪刺激时，左侧杏仁核的激活减少，右侧下额回（R IFG）的激活增加。当参与者服用艾司西酞普兰时，与安慰剂相比，负性左侧杏仁核-R IFG 的功能连接性增加，这种连接性的变化与负面刺激的主观效价和唤醒评分的降低有关。进一步的分析显示，多个额区的连接性发生了调制。结果表明，一种常用抗抑郁药的急性作用可能包括促进对负面情绪刺激的调节，为抗抑郁药作用模型提供了新的重要线索。
