Park S S, Kikkawa Y, Goldring I P, Daly M M, Zelefsky M, Shim C, Spierer M, Morita T
Am Rev Respir Dis. 1977 Jun;115(6):971-9. doi: 10.1164/arrd.1977.115.6.971.
Using beagle dogs, we have developed an animal model for the evaluation of the effect of chronic cigarette smoking on pulmonary defense and function and on lung structure. The smoking apparatus developed allows the dog actively to inhale properly diluted (1:4) smoke directly from the cigarette through a mouthpipe. In this model, 6-month and 1-year periods of mild to moderate smoking caused impairment of tracheal mucociliary transport and bacteriosuppressive activity of alveolar macrophages, with little change in pulmonary function. Morphologically, subtle, but significant, lesions were noted in the central airways and bronchiolar walls, consisting of tracheal epithelial basal cell hyperplasia, proliferation of goblet cells in central airways, and peribronchiolar infiltration by inflammatory cells. Morphometry of bronchiolar size distribution, volume proportion of parenchymal structure, and alveolar surface area, however, failed to show significant differences between the groups.
我们使用比格犬建立了一种动物模型，用于评估长期吸烟对肺部防御功能及肺结构的影响。所研发的吸烟装置能让狗通过烟嘴主动吸入经适当稀释（1:4）的直接来自香烟的烟雾。在这个模型中，6个月和1年的轻度至中度吸烟导致气管黏液纤毛运输功能受损以及肺泡巨噬细胞的抑菌活性降低，而肺功能变化不大。形态学上，在中央气道和细支气管壁发现了细微但显著的病变，包括气管上皮基底细胞增生、中央气道杯状细胞增殖以及炎性细胞在细支气管周围浸润。然而，细支气管大小分布的形态测量、实质结构的体积比例以及肺泡表面积在各组之间未显示出显著差异。
