Li Anzhang, Shao Zongze
Wei Sheng Wu Xue Bao. 2015 Apr 4;55(4):381-8.
Haloalkane dehalogenases are key enzymes for biodegradation of halogenated aliphatic compounds, widely distributed in various microbial species of wide geographical distributions, and of significance in practical application such as bioremediation and industrial biocatalysis. Twenty haloalkane dehalogenases have been biochemically characterized so far. In recent years, progresses have been made in the enzymatic characteristics, protein structures, and phylogenetic diversity. We reviewed the progresses of haloalkane dehalogenase in structure and function, diversity and application potential.
卤代烷脱卤酶是卤代脂肪族化合物生物降解的关键酶，广泛分布于地理分布广泛的各种微生物物种中，在生物修复和工业生物催化等实际应用中具有重要意义。迄今为止，已有20种卤代烷脱卤酶得到了生化特性鉴定。近年来，在酶学特性、蛋白质结构和系统发育多样性方面取得了进展。我们综述了卤代烷脱卤酶在结构与功能、多样性及应用潜力方面的研究进展。
