Xuan Hongdong, Zhang Linzhong, Liu Xueshi, Han Guomin, Li Juan, Li Xin, Liu Aiguo, Liao Mingzhi, Zhang Shihua
Department of Biostatistics, School of Science, Anhui Agricultural University, Hefei 230036, China; College of Information and Computer science, Anhui Agricultural University, Hefei 230036, China.
Department of Biostatistics, School of Science, Anhui Agricultural University, Hefei 230036, China.
Gene. 2015 Dec 1;573(2):328-32. doi: 10.1016/j.gene.2015.07.069. Epub 2015 Jul 23.
Accumulating published reports have confirmed the critical biological role (e.g., cell differentiation, gene regulation, stress response) for plant long non-coding RNAs (lncRNAs). However, a literature-derived database with the aim of lncRNA curation, data deposit and further distribution remains still absent for this particular lncRNA clade. PLNlncRbase has been designed as an easy-to-use resource to provide detailed information for experimentally identified plant lncRNAs. In the current version, PLNlncRbase has manually collected data from nearly 200 published literature, covering a total of 1187 plant lncRNAs in 43 plant species. The user can retrieve plant lncRNA entries from a well-organized interface through a keyword search by using the name of plant species or a lncRNA identifier. Each entry upon a query will be returned with detailed information for a specific plant lncRNA, including the species name, a lncRNA identifier, a brief description of the potential biological role, the lncRNA sequence, the lncRNA classification, an expression pattern of the lncRNA, the tissue/developmental stage/condition for lncRNA expression, the detection method for lncRNA expression, a reference literature, and the potential target gene(s) of the lncRNA extracted from the original reference. This database will be regularly updated to greatly facilitate future investigations of plant lncRNAs pertaining to their biological significance. The PLNlncRbase database is now freely available at http://bioinformatics.ahau.edu.cn/PLNlncRbase.
越来越多已发表的报告证实了植物长链非编码RNA(lncRNA)的关键生物学作用(如细胞分化、基因调控、应激反应)。然而,针对这一特定lncRNA分支,目前仍缺乏一个旨在对lncRNA进行整理、数据存储及进一步分发的文献数据库。PLNlncRbase被设计为一个易于使用的资源库,可为通过实验鉴定的植物lncRNA提供详细信息。在当前版本中,PLNlncRbase已从近200篇已发表文献中手动收集了数据,涵盖43种植物中的总共1187个植物lncRNA。用户可以通过使用植物物种名称或lncRNA标识符进行关键词搜索,从一个组织良好的界面检索植物lncRNA条目。每次查询返回的每个条目都将包含特定植物lncRNA的详细信息,包括物种名称、lncRNA标识符、潜在生物学作用的简要描述、lncRNA序列、lncRNA分类、lncRNA的表达模式、lncRNA表达的组织/发育阶段/条件、lncRNA表达的检测方法、参考文献以及从原始参考文献中提取的lncRNA的潜在靶基因。该数据库将定期更新,以极大地促进未来对植物lncRNA生物学意义的研究。PLNlncRbase数据库目前可在http://bioinformatics.ahau.edu.cn/PLNlncRbase免费获取。