Brain E G, Forrest A K, Hunt E, Shillingford C, Wilson J M
Beecham Pharmaceuticals, Chemotherapeutic Research Centre, Surrey, UK.
J Antibiot (Tokyo). 1989 Dec;42(12):1817-22. doi: 10.7164/antibiotics.42.1817.
Erythromycin A oxime 11,12-carbonate (5a) and its oxime ethers 5b approximately 5p have been prepared and their antibacterial activities compared with those of erythromycin A (1) and its 11,12-carbonate 2. The oxime 5a and many of its oxime ether derivatives showed good activity in vitro against Gram-positive and the more permeable Gram-negative organisms, in some cases being even more active than the carbonate 2.
已制备出红霉素A肟11,12 - 碳酸酯（5a）及其肟醚5b至5p，并将它们的抗菌活性与红霉素A（1）及其11,12 - 碳酸酯2的抗菌活性进行了比较。肟5a及其许多肟醚衍生物在体外对革兰氏阳性菌和通透性较强的革兰氏阴性菌显示出良好的活性，在某些情况下甚至比碳酸酯2更具活性。
