Radwan Michał, Jurewicz Joanna, Polańska Kinga, Sobala Wojciech, Radwan Paweł, Bochenek Michał, Hanke Wojciech
a Department of Gynecology and Reproduction , 'Gameta' Hospital , Rzgów , Poland .
b Department of Environmental Epidemiology , Nofer Institute of Occupational Medicine , Łodź , Poland , and.
Ann Hum Biol. 2016;43(1):50-6. doi: 10.3109/03014460.2015.1013986. Epub 2015 Jul 27.
Ambient air pollution has been associated with a variety of reproductive disorders. However, a limited amount of research has been conducted to examine the association between air pollution and male reproductive outcomes, specifically semen quality.
The present study was designed to address the hypothesis that exposure to fluctuating levels of specific air pollutants adversely affects sperm parameters and the level of reproductive hormones.
The study population consisted of 327 men who were attending an infertility clinic in Łodź, Poland for diagnostic purposes and who had normal semen concentration of 15-300 mln/ml. All participants were interviewed and provided a semen sample. Air quality data were obtained from AirBase database.
The statistically significant association was observed between abnormalities in sperm morphology and exposure to all examined air pollutants (PM10, PM2.5, SO2, NOX, CO). Exposure to air pollutants (PM10, PM2.5, CO, NOx) was also negatively associated with the level of testosterone. Additional exposure to PM2.5, PM10 increase the percentage of cells with immature chromatin (HDS).
The present study provides suggestive evidence of an association between ambient air pollution and sperm quality. Further research is needed to explore this association in more detail. Individual precise exposure assessment would be needed for more detailed risk characterization.
环境空气污染与多种生殖系统疾病有关。然而，针对空气污染与男性生殖结局，特别是精液质量之间关联的研究较少。
本研究旨在验证以下假设：暴露于特定空气污染物的波动水平会对精子参数和生殖激素水平产生不利影响。
研究对象为327名前往波兰罗兹一家不孕不育诊所进行诊断的男性，其精液浓度正常，为15 - 300百万/毫升。所有参与者均接受了访谈并提供了精液样本。空气质量数据来自AirBase数据库。
在精子形态异常与所有检测的空气污染物（PM10、PM2.5、SO2、NOX、CO）暴露之间观察到具有统计学意义的关联。空气污染物（PM10、PM2.5、CO、NOx）暴露也与睾酮水平呈负相关。额外暴露于PM2.5、PM10会增加未成熟染色质（HDS）细胞的百分比。
本研究为环境空气污染与精子质量之间的关联提供了提示性证据。需要进一步研究以更详细地探索这种关联。为了更详细地进行风险特征描述，需要进行个体精确暴露评估。
