使用氨基酸离子液体无偶联试剂合成二肽和三肽
Coupling-Reagent-Free Synthesis of Dipeptides and Tripeptides Using Amino Acid Ionic Liquids.
作者信息
Furukawa Shinya, Fukuyama Takahide, Matsui Akihiro, Kuratsu Mai, Nakaya Ryotaro, Ineyama Takashi, Ueda Hiroshi, Ryu Ilhyong
机构信息
Research Institute for Bioscience Products & Fine Chemicals, AminoScience Division, Ajinomoto Co., Inc. Kawasaki, Kanagawa 210-8681 (Japan).
Department of Chemistry, Graduate School of Science, Osaka Prefecture University, Sakai, Osaka 599-8531 (Japan) http://www.c.s.osakafu-u.ac.jp/∼ryu/
出版信息
Chemistry. 2015 Aug 17;21(34):11980-3. doi: 10.1002/chem.201501783. Epub 2015 Jul 17.
A general method for the synthesis of dipeptides has been developed, which does not require any coupling reagents. This method is based on the reaction of readily available HCl salts of amino acid methyl esters with tetrabutylphosphonium amino acid ionic liquids. The isolation procedure of stepwise treatment with AcOH is easy to carry out. The method was extended to the synthesis of tripeptide, tyrosyl-glycyl-glycine, present in IMREG-1, also.
已经开发出一种合成二肽的通用方法，该方法不需要任何偶联试剂。此方法基于氨基酸甲酯的盐酸盐与四丁基鏻氨基酸离子液体的反应。用乙酸逐步处理的分离步骤易于实施。该方法还扩展到了合成存在于IMREG - 1中的三肽，即酪氨酰 - 甘氨酰 - 甘氨酸。
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