Ciancarelli Irene, De Amicis Daniela, Di Massimo Caterina, Sandrini Giorgio, Pistarini Caterina, Carolei Antonio, Tozzi Ciancarelli Maria Giuliana
Funct Neurol. 2015 Jan-Mar;30(1):47-52.
The influence of intensive multifunctional neurorehabilitation on serum levels of Cu/Zn-superoxide dismutase (Cu/Zn-SOD), neuron-specific enolase (NSE), and 8-hydroxy-2-deoxyguanosine (8-OHdG), as markers of oxidative damage, was evaluated in symptomatic patients with Huntington's disease (HD). Improved clinical outcome measures were observed after neurorehabilitation. Baseline levels of Cu/Zn-SOD, NSE and 8-OHdG were higher than those observed in controls. Cu/Zn-SOD and NSE values decreased after neurorehabilitation, but were still higher than those measured in controls. Cu/Zn-SOD and NSE correlated positively before (r=0.659; p=0.003) and after rehabilitation (r=0.553, p=0.017). 8-OHdG values decreased after neurorehabilitation without reaching significance when compared with baseline values (p=0.145). No correlation was observed between the measured oxidative markers and the assessed clinical outcome measures, either before or after neurorehabilitation. The findings reported in the present paper provide evidence of the effectiveness of neurorehabilitation in reducing oxidative damage in HD patients and underline the limit of serum oxidative markers for the evaluation of clinical features of HD.
在有症状的亨廷顿舞蹈症（HD）患者中，评估了强化多功能神经康复对血清中铜锌超氧化物歧化酶（Cu/Zn-SOD）、神经元特异性烯醇化酶（NSE）和8-羟基-2-脱氧鸟苷（8-OHdG）水平的影响，这些指标作为氧化损伤的标志物。神经康复后观察到临床结局指标有所改善。Cu/Zn-SOD、NSE和8-OHdG的基线水平高于对照组。神经康复后Cu/Zn-SOD和NSE值下降，但仍高于对照组测量值。康复前（r=0.659；p=0.003）和康复后（r=0.553，p=0.017）Cu/Zn-SOD和NSE呈正相关。神经康复后8-OHdG值下降，但与基线值相比无统计学意义（p=0.145）。在神经康复前后，所测氧化标志物与评估的临床结局指标之间均未观察到相关性。本文报告的研究结果为神经康复在降低HD患者氧化损伤方面的有效性提供了证据，并强调了血清氧化标志物在评估HD临床特征方面的局限性。
