氧化应激的外周生物标志物及其在评估亨廷顿病患者临床特征方面的有限潜力。
Peripheral biomarkers of oxidative stress and their limited potential in evaluation of clinical features of Huntington's patients.
作者信息
Ciancarelli Irene, De Amicis Daniela, Di Massimo Caterina, Di Scanno Carla, Pistarini Caterina, D'Orazio Nicolantonio, Tozzi Ciancarelli Maria Giuliana
机构信息
Department of Medicine, Health, and Environmental Sciences, University of L'Aquila , L'Aquila , Italy .
出版信息
Biomarkers. 2014 Sep;19(6):452-6. doi: 10.3109/1354750X.2014.935955. Epub 2014 Jul 1.
CONTEXT
Peripheral oxidative biomarkers could be useful for monitoring clinical features of Huntington's disease (HD).
MATERIALS AND METHODS
Cu/Zn-superoxide dismutase (Cu/Zn-SOD), neuron-specific enolase (NSE) and 8-hydroxy-2'-deoxyguanosine (8-oxoGua) serum levels were analysed in 18 HD patients and 10 controls. Clinical measures were recorded from each HD patients.
RESULTS
Cu/Zn-SOD, NSE and 8-oxoGua values were higher in HD patients than in controls. Cu/Zn-SOD and NSE correlated positively. No correlation was observed between the biomarkers analysed and the clinical measures assessed.
DISCUSSION AND CONCLUSION
Serum oxidative biomarkers could express the neuronal oxidative processes going on in HD patients but are inadequate to evaluate clinical features of the disease.
背景
外周氧化生物标志物可能有助于监测亨廷顿舞蹈病（HD）的临床特征。
材料与方法
分析了18例HD患者和10例对照者的血清铜/锌超氧化物歧化酶（Cu/Zn-SOD）、神经元特异性烯醇化酶（NSE）和8-羟基-2'-脱氧鸟苷（8-氧代鸟嘌呤，8-oxoGua）水平。记录了每位HD患者的临床指标。
结果
HD患者的Cu/Zn-SOD、NSE和8-oxoGua值高于对照者。Cu/Zn-SOD和NSE呈正相关。所分析的生物标志物与所评估的临床指标之间未观察到相关性。
讨论与结论
血清氧化生物标志物可能反映HD患者体内正在进行的神经元氧化过程，但不足以评估该疾病的临床特征。
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