Zhang W, Zhang L C, Chen H, Tang P F, Zhang L H
Department of Orthopaedics, General Hospital of Chinese PLA, Beijing, China.
Department of Orthopaedics, General Hospital of Chinese PLA, Beijing, China
Genet Mol Res. 2015 Jul 13;14(3):7655-60. doi: 10.4238/2015.July.13.10.
We conducted a case-control study to assess the relation-ship between rs35767, rs2288377, and rs5742612 insulin-like growth factor-1 (IGF-1) and osteoporosis risk in a Chinese female population. The genotypes of rs35767, rs2288377, and rs5742612 of IGF-1 were determined by polymerase chain reaction-restriction fragment length polymorphism. Patients with osteoporosis were more likely to have drinking and smoking habits and have lower bone mineral density in the L2-L4 vertebrae, femoral neck, and total hip. According to conditional regression analysis, individuals carrying the TT genotype of rs35767 had an increased risk of osteoporosis, with an adjusted odds ratio (95% confidence interval) of 2.29 (1.35-4.97). In conclusion, our results sug-gest that the TT genotype of IGF-I rs35767 was associated with an in-creased risk of osteoporosis, suggesting that this polymorphism can be used as a predictive factor for osteoporosis risk.
我们进行了一项病例对照研究，以评估中国女性人群中胰岛素样生长因子-1（IGF-1）的rs35767、rs2288377和rs5742612与骨质疏松症风险之间的关系。通过聚合酶链反应-限制性片段长度多态性确定IGF-1的rs35767、rs2288377和rs5742612的基因型。骨质疏松症患者更有可能有饮酒和吸烟习惯，并且L2-L4椎体、股骨颈和全髋部的骨密度较低。根据条件回归分析，携带rsL35767的TT基因型的个体患骨质疏松症的风险增加，调整后的优势比（95%置信区间）为2.29（1.35-4.97）。总之，我们的结果表明，IGF-I rs35767的TT基因型与骨质疏松症风险增加相关，表明这种多态性可作为骨质疏松症风险的预测因素。
