Papapanagiotou Panagiotis, Xanthos Theodoros, Gulati Anil, Chalkias Athanasios, Papalois Apostolos, Kontouli Zinais, Alegakis Athanasios, Iacovidou Nicoletta
National and Kapodistrian University of Athens, Medical School, MSc "Cardiopulmonary Resuscitation", Athens, Greece; Hellenic Society of Cardiopulmonary Resuscitation, Athens, Greece.
Chicago College of Pharmacy, Department of Pharmaceutical Sciences, Midwestern University, Downers Grove, Illinois.
J Surg Res. 2016 Jan;200(1):227-35. doi: 10.1016/j.jss.2015.06.056. Epub 2015 Jun 29.
Hemorrhage is a frequent event in hospital and prehospital settings. The aim of the present study was to investigate whether centhaquin improves 24-h survival and reduces the total volume of required fluids in an established model of swine hemorrhagic shock.
Twenty-five pigs were instrumented and subjected to hemorrhagic shock. The animals were randomly allocated in two experimental groups, the control (vehicle) (n = 10) and the centhaquin groups (0.015 mg/kg, n = 10); all animals received lactated Ringer solution in the resuscitation phase until their mean arterial pressure reached 90% of the baseline. A sham group (n = 5) was added a posteriori to mimic the hemodynamic profile of the centhaquin group.
A statistically significant difference was observed in the time required for the three groups to reach their target mean aortic pressure, 36.88 ± 3.26 min for the control group versus 9.40 ± 1.01 min for the sham group and 7.10 ± 0.97 min for the centhaquin group (P < 0.001). The total amount of fluids in the control and the sham groups was significantly higher when compared with that of the centhaquin-treated animals (P < 0.001). All 10 animals in the centhaquin group survived for 24 h, whereas only three animals survived in the control group and one animal in the sham group (P = 0.002).
Centhaquin 0.015 mg/kg administered in the fluid resuscitation phase resulted in lower volume of fluids and better survival compared with control and sham-operated animals.
出血在医院和院前环境中是常见事件。本研究的目的是在已建立的猪出血性休克模型中，研究千金醌是否能提高24小时生存率并减少所需液体的总量。
25头猪进行仪器植入并遭受出血性休克。动物被随机分为两个实验组，对照组（赋形剂）（n = 10）和千金醌组（0.015 mg/kg，n = 10）；所有动物在复苏阶段接受乳酸林格氏液，直到其平均动脉压达到基线的90%。事后添加了一个假手术组（n = 5）以模拟千金醌组的心血流动力学特征。
观察到三组达到目标平均主动脉压所需时间存在统计学显著差异，对照组为36.88 ± 3.26分钟，假手术组为9.40 ± 1.01分钟，千金醌组为7.10 ± 0.97分钟（P < 0.001）。与千金醌治疗的动物相比，对照组和假手术组的液体总量显著更高（P < 0.001）。千金醌组的所有10只动物均存活24小时，而对照组仅3只动物存活，假手术组仅1只动物存活（P = 0.002）。
在液体复苏阶段给予0.015 mg/kg的千金醌，与对照组和假手术动物相比，导致液体量更低且生存率更高。
