微小RNA在结肠癌中的潜在应用：早期检测、预后及化疗敏感性
MicroRNAs potential utility in colon cancer: Early detection, prognosis, and chemosensitivity.
作者信息
Hollis Michael, Nair Kavitha, Vyas Arpita, Chaturvedi Lakshmi Shankar, Gambhir Sahil, Vyas Dinesh
机构信息
Michael Hollis, Lakshmi Shankar Chaturvedi, Sahil Gambhir, Dinesh Vyas, Department of Surgery, College of Human Medicine, Michigan State University, East Lansing, MI 48912, United States.
出版信息
World J Gastroenterol. 2015 Jul 21;21(27):8284-92. doi: 10.3748/wjg.v21.i27.8284.
Abstract
Over the past decade, research has shown that aberrant expression of microRNA (miRNA) is involved in colorectal cancer development and progression. MicroRNAs are small sequences of non-coding RNA that regulate expression of genes involved in important cellular functions, such as cell differentiation, multiplication, and apoptosis. A specific miRNA may display the effects of a tumor suppressor or oncogene. Altered miRNA expression is found in colorectal cancer (CRC) and patterns of miRNA expression correlate with CRC detection and outcome. Studies also have examined the use of circulating serum miRNA and fecal miRNA expression as non-invasive markers for early detection. Here, we review recent evidence demonstrating the potential role of miRNA in CRC and the implications of its use in the diagnosis, prognosis, and management of CRC.
摘要
在过去十年中，研究表明微小RNA（miRNA）的异常表达与结直肠癌的发生和发展有关。微小RNA是非编码RNA的小序列，可调节参与重要细胞功能（如细胞分化、增殖和凋亡）的基因表达。特定的微小RNA可能发挥肿瘤抑制因子或癌基因的作用。在结直肠癌（CRC）中发现了微小RNA表达的改变，且微小RNA表达模式与结直肠癌的检测及预后相关。研究还探讨了将循环血清微小RNA和粪便微小RNA表达作为早期检测的非侵入性标志物。在此，我们综述了近期的证据，这些证据证明了微小RNA在结直肠癌中的潜在作用及其在结直肠癌诊断、预后和管理中的意义。
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