Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Poland.
Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Poland.
Crit Rev Oncol Hematol. 2018 Dec;132:1-8. doi: 10.1016/j.critrevonc.2018.09.006. Epub 2018 Sep 15.
The discovery that microRNAs (miRNAs) - short, non-coding RNA molecules which regulate gene expression - are implicated in many types of cancer has revolutionised cancer research, giving hope for a new perspective in diagnostics and treatment. Dysregulation of miRNAs occurs in various malignancies, including colorectal cancer (CRC). CRC is one of the leading causes of cancer-related death and in most countries its incidence is still rising. Among several miRNAs which have been linked to CRC, miR-34 has attracted particular attention. This miRNA is involved in the regulation of cell cycle and apoptosis through multiple signaling pathways such as p53, Ra and Wnt signaling. Understanding its role in CRC may facilitate its future use as a diagnostic tool and therapeutic target.
miRNAs（miRNA）是一类短的、非编码的 RNA 分子，能够调节基因表达，它们与多种类型的癌症有关，这一发现彻底改变了癌症研究，为诊断和治疗提供了新的视角，带来了新的希望。miRNAs 的失调发生在各种恶性肿瘤中，包括结直肠癌（CRC）。CRC 是癌症相关死亡的主要原因之一，在大多数国家，其发病率仍在上升。在与 CRC 相关的几种 miRNA 中，miR-34 引起了特别关注。这种 miRNA 通过多种信号通路（如 p53、Ra 和 Wnt 信号通路）参与细胞周期和细胞凋亡的调节。了解其在 CRC 中的作用可能有助于将其未来用作诊断工具和治疗靶标。
