Naito H K, Mackenzie A H
Clin Chem. 1979 Mar;25(3):371-5.
We carefully selected 30 men with primary gout, rendered asymptomatic by therapy, to examine the frequency and type of hyperlipidemia and hyperlipoproteinemia, with the objective of determining whether serum uric acid, alcohol intake, liver function, kidney function, and (or) drugs were participating in the secondary lipid disorder. Sixty-one age- and sex-matched men were used as controls. About 73% of the gout patients had hypertriglyceridemia, 1.6-fold the frequency found in the control group. Types IV and IIb lipoprotein electrophoretic patterns were most prevalent in the gout group. Neither alcohol intake nor hyperuricemia, per se, seems to be the cause of the lipid and lipoprotein disorder and cannot be related to liver or kidney dysfunctions. Obesity was the major underlying factor associated with the lipidemia. The study suggests that diet and, possibly, defective clearance of triglycerides may be etiologic factors associated with the abnormal serum triacylglycerol (triglyceride) and lipoprotein concentrations in these individuals.
我们精心挑选了30名经治疗后无症状的原发性痛风男性患者，以检查高脂血症和高脂蛋白血症的发生率及类型，目的是确定血清尿酸、酒精摄入量、肝功能、肾功能和（或）药物是否与继发性脂质紊乱有关。61名年龄和性别匹配的男性作为对照。约73%的痛风患者有高甘油三酯血症，其发生率是对照组的1.6倍。IV型和IIb型脂蛋白电泳图谱在痛风组最为常见。酒精摄入量和高尿酸血症本身似乎都不是脂质和脂蛋白紊乱的原因，也与肝肾功能障碍无关。肥胖是与血脂异常相关的主要潜在因素。该研究表明，饮食以及可能存在的甘油三酯清除缺陷可能是这些个体血清三酰甘油（甘油三酯）和脂蛋白浓度异常的病因。
