治疗对原发性痛风患者红细胞磷酸核糖焦磷酸合成酶和谷胱甘肽还原酶活性的影响。
Effect of treatment on erythrocyte phosphoribosyl pyrophosphate synthetase and glutathione reductase activity in patients with primary gout.
作者信息
Braven J, Hardwell T R, Hickling P, Whittaker M
出版信息
Ann Rheum Dis. 1986 Nov;45(11):941-4. doi: 10.1136/ard.45.11.941.
Abstract
The activities of erythrocyte phosphoribosyl pyrophosphate (PRPP) synthetase and glutathione reductase (GTR) were studied in 26 patients with primary gout who were receiving no treatment or treatment with either allopurinol or azapropazone, and compared with the activity in a group of healthy controls. The activity of PRPP synthetase was significantly higher in the gout group and was not influenced by either drug. No significant difference in the activity of GTR was observed. The failure of either drug to suppress the increased activity of PRPP synthetase associated with gout is discussed.
摘要
对26例未经治疗或接受别嘌呤醇或阿扎丙宗治疗的原发性痛风患者的红细胞磷酸核糖焦磷酸（PRPP）合成酶和谷胱甘肽还原酶（GTR）活性进行了研究，并与一组健康对照者的活性进行了比较。痛风组PRPP合成酶活性显著更高，且不受任何一种药物的影响。未观察到GTR活性有显著差异。讨论了两种药物未能抑制与痛风相关的PRPP合成酶活性增加的原因。
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