Valdes Gilmer, Morin Olivier, Valenciaga Yanisley, Kirby Niel, Pouliot Jean, Chuang Cynthia
University of California.
J Appl Clin Med Phys. 2015 Jul 8;16(4):322–333. doi: 10.1120/jacmp.v16i4.5363.
The purpose of this study was to automate regular Imaging QA procedures to become more efficient and accurate. Daily and monthly imaging QA for SRS and SBRT protocols were fully automated on a Varian linac. A three-step paradigm where the data are automatically acquired, processed, and analyzed was defined. XML scripts were written and used in developer mode in a TrueBeam linac to automatically acquire data. MATLAB R013B was used to develop an interface that could allow the data to be processed and analyzed. Hardware was developed that allowed the localization of several phantoms simultaneously on the couch. 14 KV CBCTs from the Emma phantom were obtained using a TrueBeam onboard imager as example of data acquisition and analysis. The images were acquired during two months. Artifacts were artificially introduced in the images during the reconstruction process using iTool reconstructor. Support vector machine algorithms to automatically identify each artifact were written using the Machine Learning MATLAB R2011 Toolbox. A daily imaging QA test could be performed by an experienced medical physicist in 14.3 ± 2.4 min. The same test, if automated using our paradigm, could be performed in 4.2 ± 0.7 min. In the same manner, a monthly imaging QA could be performed by a physicist in 70.7 ± 8.0 min and, if fully automated, in 21.8 ± 0.6 min. Additionally, quantitative data analysis could be automatically performed by Machine Learning Algorithms that could remove the subjectivity of data interpretation in the QA process. For instance, support vector machine algorithms could correctly identify beam hardening, rings and scatter artifacts. Traditional metrics, as well as metrics that describe texture, are needed for the classification. Modern linear accelerators are equipped with advanced 2D and 3D imaging capabilities that are used for patient alignment, substantially improving IGRT treatment accuracy. However, this extra complexity exponentially increases the number of QA tests needed. Using the new paradigm described above, not only the bare minimum — but also best practice — QA programs could be implemented with the same manpower.
本研究的目的是使常规成像质量保证程序自动化,以提高效率和准确性。在瓦里安直线加速器上,立体定向放射治疗(SRS)和立体定向体部放射治疗(SBRT)协议的每日和每月成像质量保证实现了完全自动化。定义了一个三步范式,即自动采集、处理和分析数据。编写了XML脚本,并在TrueBeam直线加速器的开发者模式中使用,以自动采集数据。使用MATLAB R013B开发了一个接口,用于处理和分析数据。开发了一种硬件,可同时在治疗床上对多个模体进行定位。以使用TrueBeam机载成像仪获取艾玛模体的14千伏锥束CT(CBCT)为例,进行数据采集和分析。图像采集持续了两个月。在重建过程中,使用iTool重建器在图像中人为引入伪影。使用机器学习MATLAB R2011工具箱编写支持向量机算法,以自动识别每个伪影。一名经验丰富的医学物理学家进行每日成像质量保证测试需要14.3±2.4分钟。如果使用我们的范式进行自动化,相同的测试可在4.2±0.7分钟内完成。同样,物理学家进行每月成像质量保证需要70.7±8.0分钟,而如果完全自动化,则需要21.8±0.6分钟。此外,机器学习算法可自动进行定量数据分析,消除质量保证过程中数据解释的主观性。例如,支持向量机算法可正确识别束硬化、环形和散射伪影。分类需要传统指标以及描述纹理的指标。现代直线加速器配备了先进的二维和三维成像功能,用于患者定位,大幅提高了图像引导放射治疗(IGRT)的治疗准确性。然而,这种额外的复杂性使所需的质量保证测试数量呈指数级增加。使用上述新范式,不仅可以用相同的人力实施最低限度的质量保证计划,还可以实施最佳实践质量保证计划。