小鼠的生长激素轴与寿命
The somatotropic axis and longevity in mice.
作者信息
Brown-Borg H M
机构信息
Department of Biomedical Sciences, University of North Dakota, School of Medicine and Health Sciences, Grand Forks, North Dakota
出版信息
Am J Physiol Endocrinol Metab. 2015 Sep 15;309(6):E503-10. doi: 10.1152/ajpendo.00262.2015. Epub 2015 Jul 28.
Abstract
The somatotropic signaling pathway has been implicated in aging and longevity studies in mice and other species. The physiology and lifespans of a variety of mutant mice, both spontaneous and genetically engineered, have contributed to our current understanding of the role of growth hormone and insulin-like growth factor I on aging-related processes. Several other mice discovered to live longer than their wild-type control counterparts also exhibit differences in growth factor levels; however, the complex nature of the phenotypic changes in these animals may also impact lifespan. The somatotropic axis impacts several pathways that dictate insulin sensitivity, nutrient sensing, mitochondrial function, and stress resistance as well as others that are thought to be involved in lifespan regulation.
摘要
生长激素信号通路已被证明与小鼠和其他物种的衰老及长寿研究有关。多种自发和基因工程突变小鼠的生理学和寿命，有助于我们目前对生长激素和胰岛素样生长因子I在衰老相关过程中作用的理解。其他几种被发现比野生型对照小鼠寿命更长的小鼠，其生长因子水平也存在差异；然而，这些动物表型变化的复杂性也可能影响寿命。生长激素轴影响着多个决定胰岛素敏感性、营养感知、线粒体功能和应激抗性的通路，以及其他一些被认为参与寿命调节的通路。
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