强力霉素引起的皮肤色素沉着：病例系列

Cutaneous hyperpigmentation induced by doxycycline: a case series.

作者信息

Keijmel S P, van Kasteren M E E, Blokx W A M, van der Meer J W M, van Rossum M, Bleeker-Rovers C P

机构信息

Radboud Expert Centre for Q fever, Departments of Internal Medicine, Division of Infectious Diseases, Dermatology, Pathology, Radboudumc, Nijmegen, the Netherlands, Department of Internal Medicine, St. Elisabeth Hospital, Tilburg, the Netherlands, *corresponding author: tel.: +31(0)24-3618819, fax: +31(0)24-3541734, email:

出版信息

Neth J Med. 2015 Jan;73(1):37-40.

PMID:26219940

Abstract

Cutaneous hyperpigmentation is a well-known side effect of tetracyclines, but doxycycline-induced cutaneous hyperpigmentation has only been described in one patient with a therapeutic dosage of doxycycline, and in one patient using suprapharmacological doses. We describe four patients with cutaneous hyperpigmentation in previously unaffected skin, and speculate that this was due to treatment with doxycycline in therapeutic doses. After cessation of therapy, the hyperpigmentation diminished in all four patients, illustrating the need for recognition and timely cessation of therapy.

摘要

皮肤色素沉着是四环素类药物众所周知的副作用，但多西环素引起的皮肤色素沉着仅在1例接受治疗剂量多西环素的患者以及1例使用超药理剂量的患者中被描述过。我们描述了4例在先前未受影响的皮肤出现色素沉着的患者，并推测这是由于接受了治疗剂量的多西环素治疗所致。治疗停止后，所有4例患者的色素沉着均减轻，这表明需要认识到这一情况并及时停止治疗。