Hanshaw D M, Finnie J W, Manavis J, Kessell A E
Gribbles Veterinary Pathology (VETLAB), Adelaide, SA, Australia.
SA Pathology, Hanson Institute Centre for Neurological Diseases, Adelaide, South Australia, Australia.
Aust Vet J. 2015 Aug;93(8):283-6. doi: 10.1111/avj.12346.
An 18-month-old Angus cow presented with rapidly developing ataxia and subsequently died. The finding of large numbers of axonal spheroids in brainstem nuclei and spinal cord grey matter, bilaterally symmetrical in distribution, was consistent with a histopathological diagnosis of neuroaxonal dystrophy (NAD). Most of the axonal swellings were immunopositive to amyloid precursor protein, suggesting that interruption to axonal flow was important in their genesis.
The topographical distribution of axonal spheroids in the brain and spinal cord in this bovine case closely resembled that found in the ovine neurodegenerative disorder termed NAD, in which axonal swellings are the major pathological feature. This appears to be the first reported case of this type of NAD in cattle. The aetiology of the spheroidal aggregations in this case was not determined. There was no evidence from the case history or neuropathology to indicate whether the axonal spheroids in this case involved an acquired or heritable aetiology.
一头18个月大的安格斯母牛出现快速发展的共济失调症状，随后死亡。在脑干核和脊髓灰质中发现大量轴突球体，分布双侧对称，这与神经轴突营养不良（NAD）的组织病理学诊断一致。大多数轴突肿胀对淀粉样前体蛋白呈免疫阳性，表明轴突运输中断在其发生过程中起重要作用。
该牛病例中脑和脊髓轴突球体的分布位置与绵羊神经退行性疾病NAD中发现的情况极为相似，在NAD中轴突肿胀是主要病理特征。这似乎是牛中此类NAD的首例报道病例。该病例中球体聚集的病因尚未确定。病例史或神经病理学中没有证据表明该病例中的轴突球体涉及获得性或遗传性病因。
