ATP柠檬酸裂解酶的表达与胃腺癌的晚期阶段及预后相关。
ATP citrate lyase expression is associated with advanced stage and prognosis in gastric adenocarcinoma.
作者信息
Qian Xuchen, Hu Jiangfeng, Zhao Jiyi, Chen Hong
机构信息
Department of Gastroenterology, Zhongda Hospital, School of Medicine, Southeast University Nanjing, China.
Department of Gastroenterology, Tongji Institute of Digestive Diseases, Tongji Hospital, Tongji University School of Medicine Shanghai, China.
出版信息
Int J Clin Exp Med. 2015 May 15;8(5):7855-60. eCollection 2015.
Gastric adenocarcinoma (GA) is one of the most common cancer worldwide. ATP citrate lyase (ACLY) is generally recognized as a key enzyme of de novo fatty acid synthesis responsible for generation of oxaloacetate and cytosolic acetyl-CoA. This study aimed to investigate the expression level of ACLY in GA and evaluate the relationship between ACLY expression and the prognosis of GA patients. Paraffin archived samples from 83 GA patients were used to analyze ACLY expression by immunohistochemistry. ACLY was significantly upregulated in GA tissues compared with adjacent normal tissues (P < 0.001). High ACLY expression was correlated with advanced stages (P = 0.007) and lymph node metastasis (P = 0.022). Furthermore, patients with low ACLY expression had longer survival time than those with high ACLY expression (P = 0.031). In conclusion, these results indicate that ACLY might serve as a biomarker to predict the progression and prognosis of GA patients.
胃腺癌（GA）是全球最常见的癌症之一。ATP柠檬酸裂解酶（ACLY）通常被认为是从头脂肪酸合成的关键酶，负责生成草酰乙酸和胞质乙酰辅酶A。本研究旨在调查ACLY在GA中的表达水平，并评估ACLY表达与GA患者预后之间的关系。采用免疫组织化学方法分析83例GA患者石蜡存档样本中ACLY的表达。与相邻正常组织相比，GA组织中ACLY明显上调（P < 0.001）。ACLY高表达与晚期（P = 0.007）和淋巴结转移（P = 0.022）相关。此外，ACLY低表达患者的生存时间比ACLY高表达患者长（P = 0.031）。总之，这些结果表明ACLY可能作为预测GA患者病情进展和预后的生物标志物。
Zotero 插件