癌症患者心脏功能障碍的代谢基础。
Metabolic basis of cardiac dysfunction in cancer patients.
机构信息
Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center.
Division of Hematology and Oncology, Department of Medicine, Cedars-Sinai Medical Center.
出版信息
Curr Opin Cardiol. 2024 May 1;39(3):138-147. doi: 10.1097/HCO.0000000000001118. Epub 2024 Feb 21.
PURPOSE OF REVIEW
The relationship between metabolism and cardiovascular diseases is complex and bidirectional. Cardiac cells must adapt metabolic pathways to meet biosynthetic demands and energy requirements to maintain contractile function. During cancer, this homeostasis is challenged by the increased metabolic demands of proliferating cancer cells.
RECENT FINDINGS
Tumors have a systemic metabolic impact that extends beyond the tumor microenvironment. Lipid metabolism is critical to cancer cell proliferation, metabolic adaptation, and increased cardiovascular risk. Metabolites serve as signals which provide insights for diagnosis and prognosis in cardio-oncology patients.
SUMMARY
Metabolic processes demonstrate a complex relationship between cancer cell states and cardiovascular remodeling with potential for therapeutic interventions.
目的综述
代谢与心血管疾病之间的关系复杂且相互影响。心肌细胞必须调整代谢途径以满足生物合成需求和能量需求，从而维持收缩功能。而在癌症发生时，增殖的癌细胞会增加代谢需求，从而对这种内稳态提出挑战。
最近的发现
肿瘤具有系统代谢影响，其范围超出肿瘤微环境。脂代谢对癌细胞增殖、代谢适应和心血管风险增加至关重要。代谢物可作为信号，为心血管肿瘤患者的诊断和预后提供信息。
总结
代谢过程展示了癌细胞状态与心血管重构之间的复杂关系，为治疗干预提供了潜在的机会。
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