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OVERLOAD of joints and its role in osteoarthritis : Towards understanding and preventing progression of primary osteoarthritis. English version.

作者信息

Willie B M, Pap T, Perka C, Schmidt C O, Eckstein F, Arampatzis A, Hege H-C, Madry H, Vortkamp A, Duda G N

机构信息

Julius Wolff Institute, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.

Institute of Experimental Musculoskeletal Medicine, Westfalian Wilhelms-University Münster, Münster, Germany.

出版信息

Z Rheumatol. 2017 Mar;76(Suppl 1):1-4. doi: 10.1007/s00393-014-1561-2.

DOI:10.1007/s00393-014-1561-2
PMID:26224533
Abstract
摘要

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PTH [1-34]-induced alterations of the subchondral bone provoke early osteoarthritis.甲状旁腺激素[1-34]诱导的软骨下骨改变引发早期骨关节炎。
Osteoarthritis Cartilage. 2014 Jun;22(6):813-21. doi: 10.1016/j.joca.2014.03.010. Epub 2014 Mar 21.
2
TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading.TRPV4 介导的机械转导调节软骨细胞对动态加载的代谢反应。
Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1316-21. doi: 10.1073/pnas.1319569111. Epub 2014 Jan 13.
3
Targeting mechanotransduction pathways in osteoarthritis: a focus on the pericellular matrix.
靶向骨关节炎中的机械转导途径:聚焦细胞外基质。
Curr Opin Pharmacol. 2013 Jun;13(3):449-54. doi: 10.1016/j.coph.2013.01.010. Epub 2013 Feb 18.
4
Epidemiology and burden of osteoarthritis.骨关节炎的流行病学和负担。
Br Med Bull. 2013;105:185-99. doi: 10.1093/bmb/lds038. Epub 2013 Jan 20.
5
Bone remodelling in osteoarthritis.骨关节炎中的骨重建。
Nat Rev Rheumatol. 2012 Nov;8(11):665-73. doi: 10.1038/nrrheum.2012.130. Epub 2012 Aug 7.
6
Is lifelong knee joint force from work, home, and sport related to knee osteoarthritis?来自工作、家庭和运动的终身膝关节受力与膝关节骨关节炎有关吗?
Int J Rheumatol. 2012;2012:584193. doi: 10.1155/2012/584193. Epub 2012 Jul 17.
7
Biomechanical considerations in the pathogenesis of osteoarthritis of the knee.膝关节骨关节炎发病机制中的生物力学考虑因素。
Knee Surg Sports Traumatol Arthrosc. 2012 Mar;20(3):423-35. doi: 10.1007/s00167-011-1818-0. Epub 2011 Dec 16.
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Inflammation in osteoarthritis.骨关节炎中的炎症。
Curr Opin Rheumatol. 2011 Sep;23(5):471-8. doi: 10.1097/BOR.0b013e328349c2b1.
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WISE-2005: bed-rest induced changes in bone mineral density in women during 60 days simulated microgravity.WISE-2005:60 天模拟微重力卧床对女性骨密度的影响。
Bone. 2011 Oct;49(4):858-66. doi: 10.1016/j.bone.2011.06.021. Epub 2011 Jun 24.
10
Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis.骨小梁微结构损伤由重塑增加加重了骨质疏松症前期的实验性骨关节炎。
Arthritis Res Ther. 2010;12(4):R152. doi: 10.1186/ar3103. Epub 2010 Aug 2.