D'souza Deepti, Dandakeri Sukumar, Bhat M Ramesh, Srinath M K
Department of Dermatology, Father Muller Medical College Hospital, Mangalore, Karnataka, India.
Indian Dermatol Online J. 2015 Jul-Aug;6(4):263-5. doi: 10.4103/2229-5178.160258.
Cutaneous manifestations in antiphospholipid antibody syndrome (APS) though common, are extremely diverse and it is important to know which dermatological finding should prompt consideration of antiphospholipid syndrome. The cutaneous manifestations of APS vary from livedo reticularis to cutaneous necrosis, and systemic involvement is invariably an accomplice in APS. Cutaneous ulcers with sharp margins can be seen in APS and they are usually seen on the legs. This case had an atypical presentation, as the initial presentation was painful necrotic ulcers over the legs, which resembled pyoderma gangrenosum and she had no systemic manifestations. There was no history of any arterial or venous thrombosis or any abortions. Antiphospholipid syndrome can be tricky to diagnose when cutaneous lesions are atypical. Nonetheless, it is very important to pin down this syndrome early due to its systemic complications.
抗磷脂抗体综合征（APS）中的皮肤表现虽然常见，但极其多样，了解哪些皮肤表现应促使考虑抗磷脂抗体综合征很重要。APS的皮肤表现从网状青斑到皮肤坏死不等，并且系统性受累在APS中总是相伴出现。APS中可见边缘清晰的皮肤溃疡，通常出现在腿部。该病例表现不典型，因为最初表现为腿部疼痛性坏死性溃疡，类似坏疽性脓皮病，且无系统性表现。无任何动脉或静脉血栓形成史或流产史。当皮肤病变不典型时，抗磷脂抗体综合征可能难以诊断。尽管如此，由于其系统性并发症，早期明确诊断该综合征非常重要。
