Stolzenberg-Solomon Rachael Z, Amundadottir Laufey T
Nutritional Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Room 6E420, Rockville, MD 20850, USA.
Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 8717 Grovemont Circle, Bethesda, MD 20892, USA.
Hematol Oncol Clin North Am. 2015 Aug;29(4):619-40. doi: 10.1016/j.hoc.2015.04.009.
Given the changing demographics of Western populations, the numbers of pancreatic cancer cases are projected to increase during the next decade. Diabetes, recent cigarette smoking, and excess body weight are the cancer's most consistent risk factors. The search for common and rare germline variants that influence risk of pancreatic cancer through genome-wide association studies and high-throughput-sequencing-based studies is underway and holds the promise of increasing the knowledge of variants and genes that play a role in inherited susceptibility of this disease. Research reported in this review has advanced the understanding of pancreatic cancer.
鉴于西方人群人口结构的变化，预计未来十年胰腺癌病例数将会增加。糖尿病、近期吸烟和超重是该癌症最一致的风险因素。通过全基因组关联研究和基于高通量测序的研究来寻找影响胰腺癌风险的常见和罕见种系变异的工作正在进行中，有望增加对在该疾病遗传易感性中起作用的变异和基因的认识。本综述中报道的研究推进了对胰腺癌的理解。
