三碘甲状腺原氨酸对兰尼碱受体复合物的调节作用。
Triadin regulation of the ryanodine receptor complex.
作者信息
Marty Isabelle
机构信息
Grenoble Institut des Neurosciences, Inserm U836, Université Joseph Fourier-Bat EJ Safra, Chemin Fortuné Ferrini, 38700, La Tronche, France.
出版信息
J Physiol. 2015 Aug 1;593(15):3261-6. doi: 10.1113/jphysiol.2014.281147. Epub 2014 Oct 20.
Abstract
The calcium release complex is the major player in excitation-contraction coupling, both in cardiac and skeletal muscle. The core of the complex is the ryanodine receptor, and triadin is a regulating protein. Nevertheless, the precise function of triadin is only partially understood. Besides its function in the anchoring of calsequestrin at the triad/dyad, our recent results allow us to propose hypotheses on new triadin scaffolding functions, based on the studies performed using different models, from triadin knockout mice to human patients, and expression in non-muscle cells, taking into account the presence of multiple triadin isoforms.
摘要
钙释放复合体是心肌和骨骼肌兴奋-收缩偶联中的主要参与者。该复合体的核心是兰尼碱受体，而三联蛋白是一种调节蛋白。然而，三联蛋白的确切功能仅被部分了解。除了其在肌钙蛋白在三联体/二联体处锚定的功能外，我们最近的研究结果使我们能够基于使用不同模型（从三联蛋白基因敲除小鼠到人类患者）进行的研究以及在非肌肉细胞中的表达，并考虑到多种三联蛋白异构体的存在，提出关于三联蛋白新支架功能的假设。
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